Felipe Nör

TL;DR: It is demonstrated that an anti-5T4 antibody–drug conjugate reduces the fraction of CSCs and prevents local recurrence and suggest a novel therapeutic approach for patients with HNSCC.

TL;DR: It is hypothesized that endothelial cell-secreted interleukin-6 (IL-6) contributes to tumor progression by enhancing the migratory phenotype and survival of cancer stem cells, suggesting that endothelium cells can create a chemotactic gradient that enables the movement of carcinoma cells towards blood vessels.

TL;DR: It is demonstrated that therapeutic inhibition of the MDM2–p53 interaction with MI-773 activates downstream effectors of apoptosis and causes robust tumor regression in preclinical models of ACC.

TL;DR: It is demonstrated that single agent BM-1197 induces apoptosis and inhibits tumor growth in preclinical models of adenoid cystic carcinoma and suggests that patients with adenoids cysts carcinoma might benefit from therapy with a BH3-mimetic small molecule.