Feiye Zhou
Shanghai Jiao Tong University
18 Papers
14 Citations
Feiye Zhou is an academic researcher from Shanghai Jiao Tong University. The author has contributed to research in topics: Downregulation and upregulation & Insulin. The author has an hindex of 7, co-authored 14 publications.
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Papers
The pivotal role of protein acetylation in linking glucose and fatty acid metabolism to β-cell function.
Yuqing Zhang,Feiye Zhou,Mengyao Bai,Yun Liu,Linlin Zhang,Qin Zhu,Yufang Bi,Guang Ning,Libin Zhou,Xiao Wang +9 more
TL;DR: The first large-scale profiling of acetylome in rat islets was performed, showing that almost all enzymes in core metabolic pathways related to insulin secretion were acetylated, highlighting the potential role of protein acetylation in insulin secretion.
Berberine inhibits glucose oxidation and insulin secretion in rat islets
Mengyao Bai,Yun Liu,Feiye Zhou,Yuqing Zhang,Qin Zhu,Linlin Zhang,Qi Zhang,Shushu Wang,Kecheng Zhu,Xiao Wang,Libin Zhou +10 more
TL;DR: Berberine-mediated deceleration of glucose oxidation is tightly link to the decreased insulin secretion in islets independent of AMPK activation and inhibition of fatty acid synthesis, which may also contribute to the effect of berberine on insulin secretion.
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Berberine-induced activation of AMPK increases hepatic FGF21 expression via NUR77.
Feiye Zhou,Mengyao Bai,Yuqing Zhang,Qin Zhu,Linlin Zhang,Qi Zhang,Shushu Wang,Kecheng Zhu,Yun Liu,Xiao Wang,Libin Zhou +10 more
TL;DR: Berberine-induced activation of AMPK may contribute to hepatic FGF21 expression via NUR77, a proved transcription factor of FGF 21, and the results suggest that berberine exerts anti-hyperglycemic and anti-dyslipidemic properties.
19
Sodium butyrate potentiates insulin secretion from rat islets at the expense of compromised expression of β cell identity genes
Shushu Wang,Miaomiao Yuan,Linlin Zhang,Kecheng Zhu,Chunxiang Sheng,Feiye Zhou,Zhaoqian Xu,Qianqian Liu,Yun Liu,Jieli Lu,Xiaoju Wang,Libin Zhou +11 more
TL;DR: In this article , the role of short-chain fatty acids (SCFAs) produced by the gut microbiota have been well demonstrated to improve metabolic homeostasis and to improve pancreatic β cell function.
CBP/p300 HAT maintains the gene network critical for β cell identity and functional maturity
Linlin Zhang,Chunxiang Sheng,Feiye Zhou,Kecheng Zhu,Shushu Wang,Qianqian Liu,Miaomiao Yuan,Zhaoqian Xu,Yun Liu,Jieli Lu,Jian-min Liu,Libin Zhou,Xiao Wang +12 more
TL;DR: A-485, a selective inhibitor of CBP/p300 HAT activity, greatly impaired glucose-stimulated insulin secretion from rat islets in vitro and in vivo, and RNA-sequencing analysis showed a comprehensive downregulation of β cell and α cell identity genes in A-485-treated islets.