Feifei Xia
Jilin University
8 Papers
1 Citations
Feifei Xia is an academic researcher from Jilin University. The author has contributed to research in topics: Staphylococcus aureus & Biology. The author has an hindex of 7, co-authored 8 publications.
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Papers
Characterization of Enterococcus faecium bacteriophage IME-EFm5 and its endolysin LysEFm5
Pengjuan Gong,Mengjun Cheng,Xinwei Li,Haiyan Jiang,Chuang Yu,Nadire Kahaer,Juecheng Li,Lei Zhang,Feifei Xia,Liyuan Hu,Changjiang Sun,Xin Feng,Liancheng Lei,Wenyu Han,Jingmin Gu +14 more
TL;DR: The mutagenesis analysis revealed that the zinc ion binding residues (H27, H132, and C140), E90, and T138 are required for the catalysis of LysEFm5, and the antibacterial activity of Lys EFm5 is zinc ion independent, which is inconsistent with most of other amidase members.
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Combination Therapy of LysGH15 and Apigenin as a New Strategy for Treating Pneumonia Caused by Staphylococcus aureus
Feifei Xia,Li Xin,Bin Wang,Pengjuan Gong,Feng Xiao,Mei Yang,Lei Zhang,Jun Song,Liyuan Hu,Mengjun Cheng,Changjiang Sun,Xin Feng,Liancheng Lei,Songying Ouyang,Zhi-Jie Liu,Xinwei Li,Jingmin Gu,Wenyu Han +17 more
TL;DR: The combination therapy of LysGH15 and apigenin exhibits therapeutic potential for treating pneumonia caused by MRSA and shows the best health status, the lowest ratio of wet tissue to dry tissue of the lungs, the smallest amount of total protein and cells in the lung, the fewest pathological manifestations, and the lowest cytokine level.
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An Ointment Consisting of the Phage Lysin LysGH15 and Apigenin for Decolonization of Methicillin-Resistant Staphylococcus aureus from Skin Wounds
Mengjun Cheng,Lei Zhang,Hao Zhang,Xinwei Li,Yanmei Wang,Feifei Xia,Bin Wang,Ruopeng Cai,Zhimin Guo,Yufeng Zhang,Yalu Ji,Changjiang Sun,Xin Feng,Liancheng Lei,Yongjun Yang,Wenyu Han,Wenyu Han,Jingmin Gu +17 more
TL;DR: The potential efficacy of a combination of LysGH15 and api for use as a topical antimicrobial agent against S. aureus is demonstrated and the levels of pro-inflammatory cytokines are reduced and accelerated wound healing in the mouse model.
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Therapeutic effect of the YH6 phage in a murine hemorrhagic pneumonia model.
Mei Yang,Chongtao Du,Pengjuan Gong,Feifei Xia,Changjiang Sun,Xin Feng,Liancheng Lei,Jun Song,Lei Zhang,Bin Wang,Feng Xiao,Xinwu Yan,Ziyin Cui,Xinwei Li,Jingmin Gu,Wenyu Han +15 more
TL;DR: In view of its protective efficacy in this murine hemorrhagic pneumonia model, YH6 may serve as an alternative treatment strategy for infections caused by multidrug-resistant P. aeruginosa.
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Identification and characterization of HolGH15: the holin of Staphylococcus aureus bacteriophage GH15.
Jun Song,Feifei Xia,Haiyan Jiang,Xinwei Li,Liyuan Hu,Pengjuan Gong,Liancheng Lei,Xin Feng,Changjiang Sun,Jingmin Gu,Wenyu Han,Wenyu Han +11 more
TL;DR: To the best of the knowledge, this study is the first report of a Staphylococcus aureus phage holin that exerts antibacterial activity against heterogeneous pathogens.
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