Feifei Wang
University of Wisconsin-Madison
4 Papers
Feifei Wang is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Neural stem cell & Neurogenesis. The author has an hindex of 4, co-authored 4 publications. Previous affiliations of Feifei Wang include Fudan University.
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Papers
Fragile X Proteins FMRP and FXR2P Control Synaptic GluA1 Expression and Neuronal Maturation via Distinct Mechanisms.
Weixiang Guo,Weixiang Guo,Eric D. Polich,Juan Su,Yu Gao,Devin M. Christopher,Andrea M. Allan,Min Wang,Feifei Wang,Guangfu Wang,Xinyu Zhao +10 more
TL;DR: It is discovered thatFXR2P (also known as FXR2) is important for neuronal dendritic development and a regulatory mechanism of GluA1 is uncovered, which reveals a functional convergence between fragile X proteins in neuronal development.
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Integrative Single-Cell Transcriptomics Reveals Molecular Networks Defining Neuronal Maturation During Postnatal Neurogenesis
TL;DR: It is discovered that individual immature neurons can be classified into distinct developmental subgroups based on characteristic gene expression profiles and subgroup‐specific markers, and novel pathways involved in neuronal maturation are revealed.
Positive feedback between RNA-binding protein HuD and transcription factor SATB1 promotes neurogenesis
Feifei Wang,Joseph J Tidei,Eric D. Polich,Yu Gao,Huashan Zhao,Nora I. Perrone-Bizzozero,Weixiang Guo,Weixiang Guo,Xinyu Zhao +8 more
TL;DR: It is shown that HuD promotes neuronal differentiation of neural stem/progenitor cells in the adult subventricular zone by stabilizing the mRNA of special adenine–thymine (AT)-rich DNA-binding protein 1 (SATB1), a critical transcriptional regulator in neurodevelopment.
Reduced mitochondrial fusion and Huntingtin levels contribute to impaired dendritic maturation and behavioral deficits in Fmr1-mutant mice.
Minjie Shen,Feifei Wang,Feifei Wang,Meng Li,Nirnath Sah,Michael E. Stockton,Joseph J Tidei,Yu Gao,Tomer Korabelnikov,Sudharsan Kannan,Jason D. Vevea,Edwin R. Chapman,Anita Bhattacharyya,Henriette van Praag,Henriette van Praag,Xinyu Zhao +15 more
TL;DR: The data unveil mitochondrial dysfunction as a contributor to the impaired dendritic maturation of FMRP-deficient neurons and suggest a role for interactions between F MRP and HTT in the pathogenesis of fragile X syndrome.