Fei Wang
Tongji University
15 Papers
Fei Wang is an academic researcher from Tongji University. The author has contributed to research in topics: Biology & Medicine. The author has an hindex of 3, co-authored 8 publications.
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Papers
MicroRNA-27a controls the intracellular survival of Mycobacterium tuberculosis by regulating calcium-associated autophagy
Feng Liu,Jianxia Chen,Peng Wang,Haohao Li,Yilong Zhou,Haipeng Liu,Zhonghua Liu,Ruijuan Zheng,Lin Wang,Hua Yang,Zhenling Cui,Fei Wang,Xiaochen Huang,Jie Wang,Wei Sha,Heping Xiao,Baoxue Ge +16 more
TL;DR: It is shown that Mtb-induced MicroRNA-27a targets the ER-associated calcium transporter CACNA2D3, leading to suppression of antimicrobial autophagy and to enhanced intracellular survival of Mtb.
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cGAS facilitates sensing of extracellular cyclic dinucleotides to activate innate immunity
Haipeng Liu,Haipeng Liu,Pedro Moura-Alves,Gang Pei,Hans-Joachim Mollenkopf,Robert Hurwitz,Xiangyang Wu,Fei Wang,Siyu Liu,Mingtong Ma,Yiyan Fei,Chenggang Zhu,Anne-Britta Koehler,Dagmar Oberbeck-Mueller,Karin Hahnke,Marion Klemm,Ute Guhlich-Bornhof,Baoxue Ge,Anne Tuukkanen,Michael Kolbe,Anca Dorhoi,Anca Dorhoi,Anca Dorhoi,Stefan H. E. Kaufmann,Stefan H. E. Kaufmann +24 more
TL;DR: Endocytosis facilitates internalization of eCDNs, and the DNA sensor cGAS facilitates sensing of endocytosed CDNs, their perinuclear accumulation, and subsequent STING‐dependent release of type I IFN.
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CGAS is a micronucleophagy receptor for the clearance of micronuclei
Mengmeng Zhao,Fei Wang,Juehui Wu,Yuanna Cheng,Yajuan Cao,Xiangyang Wu,Mingtong Ma,Fen Tang,Zhi Liu,Haipeng Liu,Baoxue Ge +10 more
TL;DR: In this article, an increased frequency of micronuclei is associated with increased susceptibility to infection and increased susceptibility of the immune system to micro-microbe infection, which is a marker of genome instability and a trigger of innate immune responses.
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Cytoplasmic PARP1 links the genome instability to the inhibition of antiviral immunity through PARylating cGAS.
Fei Wang,Mengmeng Zhao,Boran Chang,Yilong Zhou,Xiangyang Wu,Ming-Ren Ma,Siyu Liu,Yajuan Cao,Mengge Zheng,Yifang Dang,Junfang Xu,Li Chen,Tianhao Liu,F. Tang,Y G Ren,Zhu Xu,Zhiyong Mao,Kai Huang,Min Luo,Jingsong Li,Haipeng Liu,Baoxue Ge +21 more
TL;DR: Ablasser et al. as mentioned in this paper showed that PARP1 is a key nuclear sensor of DNA damage, which maintains genomic integrity, and the successful application of PARP 1 inhibitors for clinical anti-cancer therapy has lasted for decades.
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CDK inhibitor Palbociclib targets STING to alleviate autoinflammation
Jiani Gao,Mengge Zheng,Xiangyang Wu,Hang Zhang,Hang Su,Yifang Dang,Ming-Ren Ma,Fei Wang,Junfang Xu,Li Chen,Tianhao Liu,Jianxia Chen,Fan Zhang,Qinghua Xu,Xuefei Hu,Heyong Wang,Yiyan Fei,Chang Chen,Haipeng Liu +18 more
TL;DR: This work identifies Palbociclib as a novel pharmacological inhibitor of STING that abrogates its homodimerization and provides a basis for the fast repurposing of this Food and Drug Administration‐approved drug for the therapy of autoinflammatory diseases.
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