Fei Duan
University of Connecticut
17 Papers
250 Citations
Fei Duan is an academic researcher from University of Connecticut. The author has contributed to research in topics: Cancer & Immune system. The author has an hindex of 8, co-authored 13 publications. Previous affiliations of Fei Duan include Memorial Sloan Kettering Cancer Center & Cornell University.
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Papers
Genomic and bioinformatic profiling of mutational neoepitopes reveals new rules to predict anticancer immunogenicity
Fei Duan,Jorge Duitama,Sahar Al Seesi,Cory M. Ayres,Steven A. Corcelli,Arpita P. Pawashe,Tatiana Blanchard,David McMahon,John Sidney,Alessandro Sette,Brian M. Baker,Ion I. Mandoiu,Pramod K. Srivastava +12 more
TL;DR: A new and improved way to predict immunoprotective cancer neoepitopes based in part on the difference in MHC-binding scores between the mutant epitope and its wild-type counterpart is defined.
Agonist anti-GITR monoclonal antibody induces melanoma tumor immunity in mice by altering regulatory T cell stability and intra-tumor accumulation.
Adam D. Cohen,David Schaer,Cailian Liu,Yanyun Li,Daniel Hirschhorn-Cymmerman,Soo Chong Kim,Adi Diab,Gabrielle Rizzuto,Gabrielle Rizzuto,Fei Duan,Fei Duan,Miguel Perales,Miguel Perales,Taha Merghoub,Alan N. Houghton,Alan N. Houghton,Jedd D. Wolchok,Jedd D. Wolchok +17 more
TL;DR: The results demonstrate that DTA-1 modulates both Teffs and Tregs during effective tumor treatment, and provide further support for the continued development of agonist anti-GITR mAbs as an immunotherapeutic strategy for cancer.
Neoadjuvant relatlimab and nivolumab in resectable melanoma
Rodabe N. Amaria,Michael A. Postow,Elizabeth M. Burton,Michael T. Tetzlaff,Merrick I. Ross,Carlos A. Torres-Cabala,Isabella C. Glitza,Fei Duan,Denái R. Milton,Klaus J. Busam,Lauren Simpson,Jennifer L. McQuade,Michael K. Wong,Jeffrey E. Gershenwald,Jeffrey E. Lee,Ryan P. Goepfert,Emily Z. Keung,Sarah B. Fisher,Allison Betof-Warner,Alexander N. Shoushtari,Margaret K. Callahan,Daniel G. Coit,Edmund K. Bartlett,Danielle M. Bello,Parisa Momtaz,Courtney Nicholas,Aidi Gu,Xuejun Zhang,Brinda Rao Korivi,Madhavi Patnana,Sapna Pradyuman Patel,Adi Diab,Anthony Lucci,Victor G. Prieto,Michael Davies,James P. Allison,Padmanee Sharma,Jennifer A. Wargo,Charlotte E. Ariyan,Hussein Abdul-Hassan Tawbi +39 more
TL;DR: In this paper , relatlimab and nivolumab combination immunotherapy was used to improve progression-free survival in patients with unresectable stage III and stage IV melanoma.
207
Perioperative nivolumab monotherapy versus nivolumab plus ipilimumab in resectable hepatocellular carcinoma: a randomised, open-label, phase 2 trial.
Ahmed Kaseb,Elshad Hasanov,Hop S. Tran Cao,Lianchun Xiao,Jean Nicolas Vauthey,Sunyoung S. Lee,Betul Yavuz,Yehia I. Mohamed,Aliya Qayyum,Sonali Jindal,Fei Duan,Sreyashi Basu,Shalini S. Yadav,Courtney Nicholas,Jingjing Sun,Kanwal Pratap Singh Raghav,Asif Rashid,Kristen Carter,Y. S. Chung,Ching Wei D. Tzeng,Divya Sakamuri,Li Nan Xu,Ryan Sun,Vittorio Cristini,Laura Beretta,James C. Yao,Robert A. Wolfe,James P. Allison,Padmanee Sharma +28 more
TL;DR: In this article , the safety and tolerability of perioperative immunotherapy in resectable hepatocellular carcinoma was evaluated in a single-centre, randomised, open-label, phase 2 trial.
170
Optimization of a self antigen for presentation of multiple epitopes in cancer immunity
José A. Guevara-Patiño,Manuel E. Engelhorn,Mary Jo Turk,Cailian Liu,Fei Duan,Gabrielle Rizzuto,Adam D. Cohen,Taha Merghoub,Jedd D. Wolchok,Alan N. Houghton +9 more
TL;DR: These studies demonstrate how rationally designed DNA vaccines directed against self antigens for enhanced antigen processing and presentation reveal novel self epitopes and elicit multi-specific T cell responses to nonimmunogenic, nonmutated self antIGens, enhancing immunity against cancer self antigelens.