Federico Giannoni
Istituto Superiore di Sanità
48 Papers
481 Citations
Federico Giannoni is an academic researcher from Istituto Superiore di Sanità. The author has contributed to research in topics: Mycobacterium tuberculosis & Tuberculosis. The author has an hindex of 21, co-authored 43 publications.
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Papers
Mycobacterium tuberculosis subverts the differentiation of human monocytes into dendritic cells
Sabrina Mariotti,Raffaela Teloni,Elisabetta Iona,Lanfranco Fattorini,Federico Giannoni,Giulia Romagnoli,Graziella Orefici,Roberto Nisini +7 more
TL;DR: The results suggest that the interference with monocyte differentiation into fully competent DC is an evasion mechanism of M. tuberculosis that could contribute to its intracellular persistence by avoiding immune recognition.
91
Rifampin Induces Hydroxyl Radical Formation in Mycobacterium tuberculosis
Giovanni Piccaro,Donatella Pietraforte,Federico Giannoni,Alessandro Mustazzolu,Lanfranco Fattorini +4 more
TL;DR: The finding that the metal chelator DTPA reduced the bactericidal activity of RIF supported the possibility that ·OH was generated through these mechanisms and that it participated at least in part in M. tuberculosis killing by the drug.
90
Drug-Resistant Tuberculosis 2020: Where We Stand
TL;DR: This review releases up-dated information on the therapeutic strategies recently endorsed and recommended by the World Health Organization to facilitate the clinical and microbiological management of drug-resistant TB at the global level, with attention also to the most recent diagnostic methods.
75
Activities of Drug Combinations against Mycobacterium tuberculosis Grown in Aerobic and Hypoxic Acidic Conditions
Giovanni Piccaro,Federico Giannoni,Perla Filippini,Alessandro Mustazzolu,Lanfranco Fattorini +4 more
TL;DR: The sterilizing effect of drug combinations against cells of different M. tuberculosis stages grown in aerobic and hypoxic acidic conditions demonstrated by lack of regrowth in MGIT, shows the most potent combination was R-MX-AK-PA, which killed all A5, H 5, H12, and H19 cells in 14 days.
68
Activity of lipophilic and hydrophilic drugs against dormant and replicating Mycobacterium tuberculosis
TL;DR: Activity of lipophilic and hydrophilic drugs against dormant and replicating Mycobacterium tuberculosis decreases with age, but the activity of these drugs increases with age.