Faye E. Nashold
University of Wisconsin-Madison
30 Papers
349 Citations
Faye E. Nashold is an academic researcher from University of Wisconsin-Madison. The author has contributed to research in topics: Experimental autoimmune encephalomyelitis & Vitamin D and neurology. The author has an hindex of 21, co-authored 30 publications.
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Papers
•Journal Article
The immunological functions of the vitamin D endocrine system.
TL;DR: A diverse and rapidly growing body of epidemiological, climatological, genetic, nutritional and biological evidence indicating that the vitamin D endocrine system functions in the establishment and/or maintenance of immunological self tolerance is reviewed.
360
IL-10 Signaling Is Essential for 1,25-Dihydroxyvitamin D3-Mediated Inhibition of Experimental Autoimmune Encephalomyelitis
TL;DR: Vitamin D3 and 1,25-(OH)2D3 may be enhancing an anti-inflammatory loop involving hemopoietic cell-produced IL-10 acting on brain parenchymal cells and vice versa, if this interpretation is correct.
229
Estrogen Controls Vitamin D3-Mediated Resistance to Experimental Autoimmune Encephalomyelitis by Controlling Vitamin D3 Metabolism and Receptor Expression
TL;DR: It is found that vitamin D3 inhibited experimental autoimmune encephalomyelitis (EAE) in intact female mice, but not in ovariectomized females or males, supporting the hypothesis that the sunlight-dependent hormone 1,25-dihydroxyvitamin D3 (1,25-(OH)2D3) is a natural inhibitor of autoimmune T cell responses in MS.
162
Vitamin A deficiency results in a priming environment conducive for Th1 cell development
TL;DR: The results show that during vitamin A deficiency, the priming environment included constitutive interleukin (IL)‐12 and IFN‐γ transcripts, but it was devoid of constitutive IL‐4 and IL‐10 transcripts, and the distorted constitutive and inducible cytokine gene expression patterns that occurred when vitamin A levels were low would be expected strongly to favor T helper type‐1 development and limit T helpers type‐2 cell growth and differentiation.
151
1,25-dihydroxyvitamin D3 treatment decreases macrophage accumulation in the CNS of mice with experimental autoimmune encephalomyelitis.
TL;DR: Possible fates for the 5 million Mac-1+ cells that were rapidly lost from the inflamed CNS in the 1,25-(OH)2D3-treated mice, and the possible beneficial effect of hormone treatment in resolving acute MS are discussed.
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