11 Papers
356 Citations
Fatim Cham is an academic researcher from Uniformed Services University of the Health Sciences. The author has contributed to research in topics: Monoclonal antibody & Epitope. The author has an hindex of 9, co-authored 11 publications. Previous affiliations of Fatim Cham include Medical Research Council.
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Papers
Identification and characterization of a new cross-reactive human immunodeficiency virus type 1-neutralizing human monoclonal antibody
Mei-Yun Zhang,Xiaodong Xiao,Igor A. Sidorov,Vidita Choudhry,Fatim Cham,Pengfei Zhang,Peter Bouma,Michael B. Zwick,Anil Choudhary,David C. Montefiori,Christopher C. Broder,Dennis R. Burton,Gerald V. Quinnan,Dimiter S. Dimitrov +13 more
TL;DR: The results suggest that m14 is a novel CD4bs cross-reactive HIV-1-neutralizing antibody that exhibits a different inhibitory profile compared to the only known potent broadly neutralizingCD4bs human antibody, b12, and may have implications for the understanding of the mechanisms of immune evasion and for the development of inhibitors and vaccines.
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Cytotoxic T Cells from Human Immunodeficiency Virus Type 2-Infected Patients Frequently Cross-React with Different Human Immunodeficiency Virus Type 1 Clades
Antonio Bertoletti,Fatim Cham,Stephen McAdam,Tim Rostron,Sarah Rowland-Jones,S Sabally,Tumani Corrah,K Ariyoshi,Hilton Whittle +8 more
TL;DR: It is demonstrated that despite the significant difference in virus amino acid sequence, the majority of HIV-2-infected individuals with different HLA molecules possess a dominant cytotoxic T-cell response which is able to recognize HIV-1 Gag protein.
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Cross-reactive HIV-1 neutralizing monoclonal antibodies selected by screening of an immune human phage library against an envelope glycoprotein (gp140) isolated from a patient (R2) with broadly HIV-1 neutralizing antibodies
Vidita Choudhry,Mei-Yun Zhang,Igor A. Sidorov,John M. Louis,Ilia Harris,Antony S. Dimitrov,Peter Bouma,Fatim Cham,Anil Choudhary,Susanna M. Rybak,Timothy R. Fouts,David C. Montefiori,Christopher C. Broder,Gerald V. Quinnan,Dimiter S. Dimitrov +14 more
TL;DR: Results indicate that the R2 Env may contain unique exposed conserved epitopes that could contribute to its ability to elicit broadly cross-reactive antibodies in animals and humans; the newly identified antibodies may help in the development of novel vaccine immunogens and therapeutics.
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HIV-2-specific cytotoxic T-lymphocyte activity is inversely related to proviral load.
TL;DR: An inverse correlation between the level of CTL activity and proviral load was found, which supports the hypothesis that CTL are important in the control of HIV-2 replication.
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