Recent discoveries of endogenous negative regulators of angiogenesis, thrombospondin, angiostatin and glioma-derived angiogenesis inhibitory factor, all associated with neovascularized tumours, suggest a new paradigm of tumorigenesis. It is now helpful to think of the switch to the angiogenic phenotype as a net balance of positive and negative regulators of blood vessel growth. The extent to which the negative regulators are decreased during this switch may dictate whether a primary tumour grows rapidly or slowly and whether metastases grow at all.

Angiogenesis in cancer, vascular, rheumatoid and other disease

Patterns and Emerging Mechanisms of the Angiogenic Switch during Tumorigenesis

Background. Experimental evidence suggests that the growth of a tumor beyond a certain size requires angiogenesis, which may also permit metastasis. To investigate how tumor angiogenesis correlates with metastases in breast carcinoma, we counted microvessels (capillaries and venules) and graded the density of microvessels within the initial invasive carcinomas of 49 patients (30 with metastases and 19 without). Methods. Using light microscopy, we highlighted the vessels by staining their endothelial cells immunocyto-chemically for factor VIII. The microvessels were carefully counted (per 200×field), and their density was graded (1 to 4+), in the most active areas of neovascularization, without knowledge of the outcome in the patient, the presence or absence of metastases, or any other pertinent variable. Results. Both microvessel counts and density grades correlated with metastatic disease. The mean (±SD) count and grade in the patients with metastases were 101±49.3 and 2.95±1.00 vessels, respect...

Tumor angiogenesis and metastasis--correlation in invasive breast carcinoma.

What is the evidence that tumors are angiogenesis dependent

Endostatin: an endogenous inhibitor of angiogenesis and tumor growth.

https://www.cell.com/cell/pdf/0092-8674(89)90238-9.pdf

Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

A method of inhibiting angiogenesis and preparations for use therein are disclosed. The preparations comprise fragments of human thrombospondin capable of inhibiting vascularization. The method and preparations are especially applicable to the treatment of solid tumors including skin cancers for controlling tumor neovascularization and thereby arresting tumor enlargement.

Method of inhibiting angiogenesis of tumors

Assay and purification of naturally occurring inhibitor of angiogenesis.

L'invention se rapporte a un procede inhibiteur d'angiogenese ainsi qu'a des preparations utilisables dans ce procede. Les preparations contiennent des fragments de thrombospondine humaine capables d'inhiber la vascularisation. Ce procede et ces preparations s'appliquent en particulier dans le traitement de tumeurs pleines, telles que les cancers de la peau, en vue d'empecher la neovascularisation des tumeurs et arreter ainsi leur developpemnent.

Procede inhibiteur de l'angiogenese tumorale

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Regulation of the activity of a new inhibitor of angiogenesis by a cancer suppressor gene

Method of inhibiting angiogenesis of tumors

Assay and purification of naturally occurring inhibitor of angiogenesis.

Procede inhibiteur de l'angiogenese tumorale