Fansen Meng
Life Sciences Institute
16 Papers
11 Citations
Fansen Meng is an academic researcher from Life Sciences Institute. The author has contributed to research in topics: Biology & Innate immune system. The author has an hindex of 5, co-authored 7 publications. Previous affiliations of Fansen Meng include Zhejiang University.
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Papers
HER2 recruits AKT1 to disrupt STING signalling and suppress antiviral defence and antitumour immunity.
Shiying Wu,Qian Zhang,Qian Zhang,Fei Zhang,Fansen Meng,Fansen Meng,Shengduo Liu,Ruyuan Zhou,Qingzhe Wu,Xinran Li,Li Shen,Jun Huang,Jun Qin,Songying Ouyang,Zongping Xia,Hai Song,Xin-Hua Feng,Xin-Hua Feng,Jian Zou,Pinglong Xu,Pinglong Xu +20 more
TL;DR: It is demonstrated that HER2 recruits AKT1 to disrupt the STING signalosome, thereby suppressing damage-induced cellular senescence and STING-mediated antiviral and antitumour responses in vivo.
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Hippo signalling governs cytosolic nucleic acid sensing through YAP/TAZ-mediated TBK1 blockade
Qian Zhang,Fansen Meng,Shasha Chen,Steven W. Plouffe,Shiying Wu,Shengduo Liu,Xinran Li,Ruyuan Zhou,Junxian Wang,Bin Zhao,Jianming Liu,Jun Qin,Jian Zou,Xin-Hua Feng,Xin-Hua Feng,Kun-Liang Guan,Pinglong Xu +16 more
TL;DR: YAP/TAZ act as natural inhibitors of TBK1 and are vital for antiviral physiology and the Hippo pathway is described, by linking cellular nutrient/physical status to antiviral host defence.
Mst1 shuts off cytosolic antiviral defense through IRF3 phosphorylation
Fansen Meng,Ruyuan Zhou,Shiying Wu,Qian Zhang,Qiuheng Jin,Yao Zhou,Steven W. Plouffe,Shengduo Liu,Hai Song,Zongping Xia,Bin Zhao,Sheng Ye,Xin-Hua Feng,Kun-Liang Guan,Jian Zou,Pinglong Xu +15 more
TL;DR: The identification of Mst1 as a novel physiological negative regulator of IRF3 activation provides mechanistic insights into innate antiviral defense and potential antiviral prevention strategies.
Lck/Hck/Fgr-Mediated Tyrosine Phosphorylation Negatively Regulates TBK1 to Restrain Innate Antiviral Responses.
Shengduo Liu,Shasha Chen,Xinran Li,Shiying Wu,Qian Zhang,Qiuheng Jin,Lin Hu,Ruyuan Zhou,Zhengyang Yu,Fansen Meng,Siwen Wang,Yao-Wei Huang,Sheng Ye,Li Shen,Zongping Xia,Jian Zou,Xin-Hua Feng,Pinglong Xu +17 more
TL;DR: The negative regulation of TBK1 via tyrosine phosphorylation and the functional integration of SFKs into innate antiviral immunity are unveiled.
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AMPK directly phosphorylates TBK1 to integrate glucose sensing into innate immunity.
Qian Zhang,Shengduo Liu,Chen-Song Zhang,Qirou Wu,Xinyuan Yu,Ruyuan Zhou,Fansen Meng,Ailian Wang,Fei Zhang,Shasha Chen,Xiaojian Wang,Lei Li,Jun Huang,Yaoping Huang,Jian Zou,Jun Qin,Tingbo Liang,Xin-Hua Feng,Sheng-Cai Lin,Pinglong Xu +19 more
TL;DR: In this article , the authors found that viral infection led to a rapid and dramatic decrease in blood glucose levels in rodents, leading to robust AMPK activation, and revealed the molecular mechanism coupling a dual sensing of glucose and nuclei acids, and report its physiological necessity in antiviral defense.
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