Fangwei Li
Xi'an Jiaotong University
16 Papers
52 Citations
Fangwei Li is an academic researcher from Xi'an Jiaotong University. The author has contributed to research in topics: Cancer & PI3K/AKT/mTOR pathway. The author has an hindex of 8, co-authored 15 publications.
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Papers
SphK1/S1P mediates TGF-β1-induced proliferation of pulmonary artery smooth muscle cells and its potential mechanisms.
Jian Wang,Wei Feng,Fangwei Li,Wenhua Shi,Cui Zhai,Shaojun Li,Yanting Zhu,Xin Yan,Qingting Wang,Lu Liu,Xinming Xie,Manxiang Li +11 more
TL;DR: This study indicates that Smad2/3/SphK1/S1P/Notch3 pathway mediates TGF-β1-induced PASMC proliferation and suggests this pathway as a potential therapeutic target in the prevention and treatment of pulmonary hypertension.
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SphK1/S1P Mediates PDGF-Induced Pulmonary Arterial Smooth Muscle Cell Proliferation via miR-21/BMPRII/Id1 Signaling Pathway.
Fangwei Li,Jian Wang,Yanting Zhu,Lu Liu,Wei Feng,Wenhua Shi,Qingting Wang,Qianqian Zhang,Limin Chai,Manxiang Li +9 more
TL;DR: It is indicated that SphK 1/S1P pathway plays an important role in PDGF-induced PASMC proliferation via miR-21/BMPRII/Id1 axis and targeting against SphK1/S 1P axis might be a novel strategy in the prevention and treatment of pulmonary arterial hypertension (PAH).
Activation of peroxisome proliferator-activated receptor γ ameliorates monocrotaline-induced pulmonary arterial hypertension in rats
Xinming Xie,Guizuo Wang,Dexin Zhang,Yonghong Zhang,Yanting Zhu,Fangwei Li,Shaojun Li,Manxiang Li +7 more
TL;DR: Activation of PPARγ ameliorates the proliferation of PASMCs and vascular remodeling by regulating the PTEN/PI3K/Akt pathway, suggesting that the activation ofPPARγ has potential benefits for PAH.
Knockdown of AMPKα2 Promotes Pulmonary Arterial Smooth Muscle Cells Proliferation via mTOR/Skp2/p27Kip1 Signaling Pathway
Rui Ke,Lu Liu,Yanting Zhu,Shaojun Li,Xinming Xie,Fangwei Li,Yang Song,Lan Yang,Li Gao,Manxiang Li +9 more
TL;DR: This study indicates that AMPK α2 isoform plays an important role in regulation of PASMCs proliferation by modulating mTOR/Skp2/p27Kip1 axis, and suggests that activation of AMPKα2 might have potential value in the prevention and treatment of pulmonary arterial hypertension.
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•Journal Article
Interleukin-6 gene -174G/C polymorphism and bronchial asthma risk: a meta-analysis
TL;DR: It is indicated that IL-6 -174 CC genotype may be a protective factor against asthma in Caucasian and adults.
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