Fanghao Lu
Harbin Medical University
41 Papers
135 Citations
Fanghao Lu is an academic researcher from Harbin Medical University. The author has contributed to research in topics: Mitochondrion & Calcium in biology. The author has an hindex of 20, co-authored 34 publications.
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Papers
Role of the Calcium-Sensing Receptor in Cardiomyocyte Apoptosis via the Sarcoplasmic Reticulum and Mitochondrial Death Pathway in Cardiac Hypertrophy and Heart Failure
Fanghao Lu,Songbin Fu,Xiaoning Leng,Xinying Zhang,Shiyun Dong,Yajun Zhao,Huan Ren,Hulun Li,Xin Zhong,Changqing Xu,Weihua Zhang +10 more
TL;DR: It is demonstrated that CaR activation caused Ca2+ release from the SR into the mitochondria and induced cardiomyocyte apoptosis through the SR and mitochondrial apoptotic pathway in failing hearts.
Exogenous H2S Protects Against Diabetic Cardiomyopathy by Activating Autophagy via the AMPK/mTOR Pathway.
Fan Yang,Linxue Zhang,Zhaopeng Gao,Xiaojiao Sun,Miao Yu,Shiyun Dong,Jichao Wu,Yajun Zhao,Changqing Xu,Weihua Zhang,Fanghao Lu +10 more
TL;DR: The findings demonstrated that H2S decreases oxidative stress and protects against mitochondria injury, activates autophagy, and eventually leads to cardiac protection via the AMPK/mTOR pathway.
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Exogenous H2S Promoted USP8 Sulfhydration to Regulate Mitophagy in the Hearts of db/db Mice.
Yu Sun,Fanghao Lu,Xiangjing Yu,Bingzhu Wang,Jian Chen,Fangping Lu,Shuo Peng,Xiaojiao Sun,Miao Yu,He Chen,Yan Wang,Linxue Zhang,Ning Liu,Haining Du,Dechao Zhao,Weihua Zhang +15 more
TL;DR: It is found that exogenous H2S could improve cardiac functions, reduce mitochondrial fragments and ROS levels, enhance mitochondrial respiration chain activities and inhibit mitochondrial apoptosis in the hearts of db/db mice.
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Post-conditioning protects cardiomyocytes from apoptosis via PKCε-interacting with calcium-sensing receptors to inhibit endo(sarco)plasmic reticulum-mitochondria crosstalk
Shiyun Dong,Zongyan Teng,Fanghao Lu,Yajun Zhao,Hulun Li,Huan Ren,He Chen,Zhenwei Pan,Yan-jie Lv,Baofeng Yang,Ye Tian,Changqing Xu,Weihua Zhang +12 more
TL;DR: Results suggested that PKCε interacting with CaR protected post-conditioned cardiomyocytes from programmed cell death by inhibiting disruption of the mitochondria by the ER as well as preventing calcium-induced signaling of the apoptotic pathway.
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Hydrogen Sulphide modulating mitochondrial morphology to promote mitophagy in endothelial cells under high-glucose and high-palmitate
Ning Liu,Jichao Wu,Linxue Zhang,Zhaopeng Gao,Yu Sun,Miao Yu,Yajun Zhao,Shiyun Dong,Fanghao Lu,Weihua Zhang +9 more
TL;DR: Exogenous H2S could protect RAECs against apoptosis under high glucose and palmitate by suppressing oxidative stress, decreasing mitochondrial fragments and promoting mitophagy.
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