Fang-Yu Chen
National Central University
12 Papers
122 Citations
Fang-Yu Chen is an academic researcher from National Central University. The author has contributed to research in topics: Lipid bilayer & Membrane fluidity. The author has an hindex of 12, co-authored 12 publications. Previous affiliations of Fang-Yu Chen include Rice University.
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Papers
The condensing effect of cholesterol in lipid bilayers.
TL;DR: The condensing effect of cholesterol on phospholipid bilayers was systematically investigated for saturated and unsaturated chains, as a function of cholesterol concentration, using X-ray lamellar diffraction to measure the phosphate-to-phosphate distances.
421
Molecular mechanism of Peptide-induced pores in membranes.
TL;DR: A physical mechanism by which antimicrobial peptides spontaneously induce stable pores in membranes is suggested, which resembles a phase transition.
Evidence for membrane thinning effect as the mechanism for peptide-induced pore formation.
TL;DR: The full implications of the free energy were tested by including another type of peptide, melittin, that forms toroidal pores, instead of barrel-stave pores as in the case of alamethicin, indicating that the membrane thinning effect is a plausible mechanism for the peptide-induced pore formations.
301
Energetics of pore formation induced by membrane active peptides
TL;DR: This work uses two of the best-studied peptides, alamethicin and melittin, to represent peptides making two types of pores, that is, barrel-stave pores and toroidal pores, and extracts experimental parameters that are useful for further molecular analysis and for molecular dynamic simulation studies.
Mechanism and kinetics of pore formation in membranes by water-soluble amphipathic peptides
TL;DR: The mechanism includes a negative feedback that makes peptide-induced pores stable with a well defined size, contrary to the suggestion that peptides disintegrate the membrane in a detergent-like manner.