Fang Wang
Albert Einstein College of Medicine
4 Papers
59 Citations
Fang Wang is an academic researcher from Albert Einstein College of Medicine. The author has contributed to research in topics: Binding site & Acetylation. The author has an hindex of 4, co-authored 4 publications.
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Papers
SIRT1 deacetylation and repression of p300 involves lysine residues 1020/1024 within the cell cycle regulatory domain 1.
Toula Bouras,Maofu Fu,Anthony A. Sauve,Fang Wang,Andrew A. Quong,Neil D. Perkins,Ronald T. Hay,Wei Gu,Richard G. Pestell +8 more
TL;DR: The p300 protein serves as a rate-limiting transcriptional cointegrator of diverse transcription factors either to activate or to repress transcription through modular subdomains and may serve an important integration point during metabolism and cellular differentiation.
366
Probing the molecular basis for potent and selective protein-tyrosine phosphatase 1B inhibition.
TL;DR: The results provide structural information toward understanding of the molecular basis for potent and selective PTP1B inhibition and further establish the feasibility of acquiring potent, yet highly selective, PTP inhibitory agents.
79
Mapping ERK2-MKP3 binding interfaces by hydrogen/deuterium exchange mass spectrometry.
TL;DR: The results show that the exquisite specificity of MKP3 for ERK2 is governed by two distinctive protein-protein interactions, which may be applicable to the recognition of other MAPKs by their cognate regulators and substrates.
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Hormonal Control of Androgen Receptor Function through SIRT1
Maofu Fu,Manran Liu,Anthony A. Sauve,Xuanmao Jiao,Xueping Zhang,Xiaofang Wu,Michael J. Powell,Tianle Yang,Wei Gu,Maria Laura Avantaggiati,Nagarajan Pattabiraman,Timothy G. Pestell,Fang Wang,Andrew A. Quong,Chenguang Wang,Richard G. Pestell +15 more
TL;DR: DHT-induced prostate cancer cellular contact-independent growth is also blocked by SIRT1, providing a direct functional link between the AR, which is a critical determinant of progression of human prostate cancer, and the sirtuins.