Fang Bai
ShanghaiTech University
55 Papers
153 Citations
Fang Bai is an academic researcher from ShanghaiTech University. The author has contributed to research in topics: Chemistry & Medicine. The author has an hindex of 23, co-authored 48 publications. Previous affiliations of Fang Bai include East China University of Science and Technology & Chinese Academy of Sciences.
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Papers
Structure of Mpro from SARS-CoV-2 and discovery of its inhibitors
Zhenming Jin,Zhenming Jin,Xiaoyu Du,Yechun Xu,Yong-Qiang Deng,Meiqin Liu,Yao Zhao,Bing Zhang,Xiaofeng Li,Leike Zhang,Chao Peng,Yinkai Duan,Jing Yu,Lin Wang,Kailin Yang,Fengjiang Liu,Ren-Di Jiang,Xing-Lou Yang,Tian You,Liu X,Xiuna Yang,Fang Bai,Hong Liu,Xiang Liu,Luke W. Guddat,Wenqing Xu,Wenqing Xu,Gengfu Xiao,Cheng-Feng Qin,Zhengli Shi,Hualiang Jiang,Hualiang Jiang,Zihe Rao,Zihe Rao,Zihe Rao,Haitao Yang +35 more
TL;DR: A programme of structure-assisted drug design and high-throughput screening identifies six compounds that inhibit the main protease of SARS-CoV-2, demonstrating the ability of this strategy to isolate drug leads with clinical potential.
Structure-based design of antiviral drug candidates targeting the SARS-CoV-2 main protease.
Wenhao Dai,Wenhao Dai,Bing Zhang,Xia Ming Jiang,Haixia Su,Jian Li,Jian Li,Yao Zhao,Xiong Xie,Zhenming Jin,Jingjing Peng,Fengjiang Liu,Chunpu Li,You Li,Fang Bai,Haofeng Wang,Xi Cheng,Xiaobo Cen,Shulei Hu,Xiuna Yang,Jiang Wang,Xiang Liu,Gengfu Xiao,Hualiang Jiang,Zihe Rao,Lei Ke Zhang,Yechun Xu,Haitao Yang,Hong Liu +28 more
TL;DR: Two peptidomimetic aldehydes were designed, synthesized, and evaluated as antiviral drug candidates, and both exhibited excellent inhibitory activity and potent anti-SARS-CoV-2 infection activity.
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Structural Basis for Molecular Recognition at Serotonin Receptors
Chong Wang,Yi Jiang,Yi Jiang,Jinming Ma,Jinming Ma,Huixian Wu,Daniel Wacker,Vsevolod Katritch,Gye Won Han,Wei Liu,Xi Ping Huang,Eyal Vardy,John D. McCorvy,Xiang Gao,X. Edward Zhou,Karsten Melcher,Chenghai Zhang,Fang Bai,Huaiyu Yang,Linlin Yang,Hualiang Jiang,Bryan L. Roth,Vadim Cherezov,Raymond C. Stevens,H. Eric Xu +24 more
TL;DR: Crystal structures of the human 5-HT1B G protein–coupled receptor bound to the agonist antimigraine medications ergotamine and dihydroergotamine are reported and provide a comprehensive structural basis for understanding receptor-ligand interactions and designing subtype-selective serotonergic drugs.
Anti-SARS-CoV-2 activities in vitro of Shuanghuanglian preparations and bioactive ingredients.
Hai xia Su,Sheng Yao,Wen feng Zhao,Min jun Li,Jia Liu,Wei juan Shang,Hang Xie,Chang Qiang Ke,Hang chen Hu,Mei na Gao,Kun qian Yu,Hong Liu,Jingshan Shen,Wei Tang,Lei Ke Zhang,Gengfu Xiao,Li Ni,Dao Wen Wang,Jianping Zuo,Hualiang Jiang,Hualiang Jiang,Fang Bai,Yan Wu,Yang Ye,Ye chun Xu +24 more
TL;DR: Baicalin and baicalein, two ingredients of Shuanghuanglian, were characterized as the first noncovalent, nonpeptidomimetic inhibitors of SARS-CoV-2 3CLpro and exhibited potent antiviral activities in a cell-based system.
Targeting CPT1A-mediated fatty acid oxidation sensitizes nasopharyngeal carcinoma to radiation therapy
Zheqiong Tan,Lanbo Xiao,Lanbo Xiao,Min Tang,Min Tang,Fang Bai,Jiangjiang Li,Liling Li,Liling Li,Feng Shi,Feng Shi,Namei Li,Namei Li,Yueshuo Li,Yueshuo Li,Qianqian Du,Qianqian Du,Jingchen Lu,Jingchen Lu,Xinxian Weng,Xinxian Weng,Wei Yi,Wei Yi,Hanwen Zhang,Jia Fan,Jian Zhou,Qiang Gao,José N. Onuchic,Ann M. Bode,Xiangjian Luo,Xiangjian Luo,Ya Cao +31 more
TL;DR: FAO was active in radiation-resistant NPC cells, and the rate-limiting enzyme of FAO, carnitine palmitoyl transferase 1 A (CPT1A), was consistently up-regulated in these cells, where the protein level of CPT1A was significantly associated with poor overall survival of NPC patients following radiotherapy.
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