Fan Zeng

TL;DR: The Chinese Glioma Genome Atlas (CGGA) is developed, a user-friendly data portal for storage and interactive exploration of multi-dimensional functional genomic data that includes nearly 2,000 primary and recurrent glioma samples from Chinese cohorts and develops an analysis tool to allow users to browse mutational, mRNA/microRNA expression, and DNA methylation profiles and perform survival and correlation analyses of specificglioma subtypes.

TL;DR: A MET kinase inhibitor is described, PLB-1001, that demonstrates remarkable potency in selectively inhibiting MET-altered tumor cells in preclinical models and shows blood-brain barrier permeability and is subsequently applied in a phase I clinical trial that enrolls MET- altered chemo-resistant glioma patients.

TL;DR: The Chinese Glioma Genome Atlas (CGGA), a user-friendly data portal for the storage and interactive exploration of cross-omics data, including nearly 2000 primary and recurrent glioma samples from Chinese cohort, is developed.

TL;DR: Wang et al. as mentioned in this paper constructed an ER stress-related risk signature to investigate the functional roles of ER stress in gliomas, and evaluated the prognostic value of the risk signature by Cox regression, Kaplan-Meier and ROC Curve analyses.