Differencing between strictly sequential and parallel models has a great importance in todays psicophysiological investigation. Most of the studies realize...

Potenciales evocados auditivos de larga latencia (PEALL) relacionados con el procesamiento de la información

Purpose: Attention decline after stroke is common and hampers the rehabilitation process, and non-invasive transcranial direct current stimulation (tDCS) has the potential to elicit behavioral changes by modulating cortical excitability. The authors tested the hypothesis that a single session of non-invasive cortical stimulation with excitatory anodal tDCS applied to the left dorsolateral prefrontal cortex (DLPFC) can improve attention in stroke patients. Methods: Ten patients with post-stroke cognitive decline (MMSE 25) and 10 age-matched healthy controls participated in this double blind, sham-controlled, crossover study involving the administration of real (2 mA for 20 min) or sham stimulation (2 mA for 1 min) to the left DLPFC. Attention was measured using a computerized Go/No-Go test before and after intervention. Improvements in accuracy and speed after stimulation relative to baseline were compared for real and sham stimulations. Results: In healthy controls, no significant improvement in Go/No-Go test was observed after either real or sham stimulation. However, in stroke patients, tDCS led to a significant improvement in response accuracy at 1 hour post-stimulation relative to baseline, and this improvement was maintained until 3 hours post-stimulation ( P 0.05). Changes in reaction times were comparable for the two stimulations ( P> 0.05). Conclusion: Non invasive anodal tDCS applied to the left DLPFC was found to improve attention versus sham stimulation in stroke patients, which suggests that non-invasive cortical intervention could potentially be used during rehabilitative training to improve attention.

/pdf/non-invasive-cortical-stimulation-improves-post-stroke-4t14a7oxge.pdf

Non-invasive cortical stimulation improves post-stroke attention decline.

OBJECTIVES The aim of the study was the short term test-retest-reliability of electrophyisiological correlates of simple processes of the motor control, i.e. the execution (go) and the inhibition (no go) of a prepared motor response, evoked during the Continuous Performance Test (CPT). Our interest was centered in the reliability of the topographical P300-parameters described in previous studies, i.e. the localizations of the go and no go centroids and the no go anteriorization (NGA), which is the difference between the two centroid locations. A sufficient reliability is a basic requirement for the application of these new topographical parameters for the investigation of different psychiatric illnesses with suspected dysfunctions of prefrontal motor control, e.g. schizophrenias and affective illnesses, obsessive-compulsive disorders, personality disorders with deficits in impulse control, and in children with attention deficit hyperactivity disorder. PATIENTS AND METHODS We examined 23 healthy subjects who executed two versions of the CPT with an interval of 30 minutes. After averaging the obtained evoked potentials of each subject, we determined the latencies, amplitudes and positive centroids, at the moment of the peak of the Global Field Power in a P300 time window. RESULTS Statistical analysis revealed sufficient test-retest-reliabilities in comparison to other electrophysiological paradigms, mainly for the localizations of the go (r = 0.93; p = 10(-10)) and no go centroid (r = 0.85; p = 10(-4)), as well as for the no go anteriorization (r = 0.63; p = 10(-3)). CONCLUSION These results are a prerequisite for the application of these topographical parameters as measures of the prefrontal motor control in different healthy and psychiatric populations.

Reliability of electrophysiological measurements of motor control

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Reliability of electrophysiological measurements of motor control