Fadeng Yang
Peking University
7 Papers
17 Citations
Fadeng Yang is an academic researcher from Peking University. The author has contributed to research in topics: Fibril & Protein aggregation. The author has an hindex of 3, co-authored 4 publications.
Chat about Author
Papers
Conformation Dependence of Diphenylalanine Self-Assembly Structures and Dynamics: Insights from Hybrid-Resolution Simulations.
TL;DR: The hybrid-resolution modeling method demonstrated here can be employed to investigate the role that conformation plays during the assembly of terminally capped diphenylalanines (FF) through microsecond simulations of hundreds or thousands of peptides, and shows promise for studying peptide-assembled nanostructures and their rational design.
55
α-Helical Motif as Inhibitors of Toxic Amyloid-β Oligomer Generation via Highly Specific Recognition of Amyloid Surface.
Yixiang Jiang,Xuehan Jiang,Xiaodong Shi,Fadeng Yang,Yang Cao,Xuan Qin,Zhanfeng Hou,Mingsheng Xie,Na Liu,Qi Fang,Feng Yin,Wei Han,Zigang Li +12 more
TL;DR: This work demonstrates, for the first time, a rational design of alpha-helical peptide inhibitors targeting the amyloid-beta 40 (Aβ40) fibril surfaces, based on the in silico finding that a helical fragment of Aβ40 interacts in a unique way with side-chain arrays on the fibrIL surface.
15
Therapeutic potential for amyloid surface inhibitor: only amyloid‐β oligomers formed by secondary nucleation disrupt lipid membrane integrity
TL;DR: This study highlights the therapeutic potential for inhibiting secondary nucleation process in Aβ aggregation, rather than inhibiting all pathways to fibril formation, by incubating Aβ monomers with cHASI and showing that only oligomers produced during secondary surface nucleation disrupt membrane integrity.
10
Targeting the Amyloid-β Fibril Surface with a Constrained Helical Peptide Inhibitor.
TL;DR: It is demonstrated that in-tether chiral center-induced helical stabilized peptides were also able to recognize the fibril surfaces, effectively inhibiting the surface-mediated oligomerization of Aβ40.
5
Pyridinium-Based Strategy for a Bioorthogonal Conjugation-Assisted Purification Method for Profiling Cell Surface Proteome.
Chuan Dai,Xiaochun Guo,Zhuoheng Pan,Chuan Wan,Dongyan Yang,Yongli Li,Chenshan Lian,Yuhao An,Tuanjie Zhang,Fadeng Yang,Lizhi Zhu,Feng Yin,Rui Wang,Zigang Li +13 more
TL;DR: The SPE probe showed higher efficiency in labeling proteins than similar NHS esters at the level of cell lysates and demonstrated specificity for Lys in competitive experiments, demonstrating that the SPE method provides a promising tool for the selective labeling of cell surface proteins and monitoring transient cell surface events.
3