Fabrice E. Graf
University of Basel
17 Papers
42 Citations
Fabrice E. Graf is an academic researcher from University of Basel. The author has contributed to research in topics: Trypanosoma brucei & Pentamidine. The author has an hindex of 8, co-authored 17 publications. Previous affiliations of Fabrice E. Graf include University of Gothenburg & Swiss Tropical and Public Health Institute.
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Papers
Trypanosoma brucei aquaglyceroporin 2 is a high-affinity transporter for pentamidine and melaminophenyl arsenic drugs and the main genetic determinant of resistance to these drugs
Jane C. Munday,Anthonius A. Eze,Anthonius A. Eze,Nicola Baker,Lucy Glover,Caroline Clucas,David Aguinaga Andrés,Manal J. Natto,Ibrahim A. Teka,Jennifer McDonald,Rebecca S. Lee,Fabrice E. Graf,Fabrice E. Graf,Philipp Ludin,Philipp Ludin,Richard Burchmore,C. Michael R. Turner,Andy Tait,Annette MacLeod,Pascal Mäser,Pascal Mäser,Michael P. Barrett,David Horn,Harry P. de Koning +23 more
TL;DR: TbA QP2 mediates high-affinity uptake of pentamidine and melaminophenyl arsenicals in trypanosomes and TbAQP2 encodes the previously reported HAPT1 activity, which establishes Tb aQP 2 as an important drug transporter.
Aquaporin 2 Mutations in Trypanosoma brucei gambiense Field Isolates Correlate with Decreased Susceptibility to Pentamidine and Melarsoprol
Fabrice E. Graf,Philipp Ludin,Philipp Ludin,Tanja Wenzler,Tanja Wenzler,Marcel Kaiser,Marcel Kaiser,Reto Brun,Reto Brun,Patient Pati Pyana,Philippe Büscher,Harry P. de Koning,David Horn,Pascal Mäser,Pascal Mäser +14 more
TL;DR: Two different kinds of TbAQP2 mutations found in T. b.
Inhibiting conjugation as a tool in the fight against antibiotic resistance.
TL;DR: This commentary highlights one relatively unexplored target for drug development: conjugation, a common mechanism of horizontal gene transfer in bacteria that is instrumental in the spread of antibiotic resistance among bacteria.
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BK Polyomavirus Evades Innate Immune Sensing by Disrupting the Mitochondrial Network and Promotes Mitophagy
Julia Manzetti,Fabian H. Weissbach,Fabrice E. Graf,Gunhild Unterstab,Marion Wernli,Helmut Hopfer,Cinthia B. Drachenberg,Christine Hanssen Rinaldo,Hans H. Hirsch,Hans H. Hirsch +9 more
TL;DR: It is reported that BKPyV disrupts the mitochondrial network and membrane potential when expressing the 66aa-long agnoprotein during late replication, indicating a conserved mechanism facilitating polyomavirus persistence and post-transplant disease.
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Trypanosoma brucei adenine-phosphoribosyltransferases mediate adenine salvage and aminopurinol susceptibility but not adenine toxicity
TL;DR: In this paper, the authors report on the T. brucei adenine phosphoribosyltransferases TbAPRT1 and TbapRT2, encoded by the two genes Tb927.7.1780 and tb 927.1790, located in tandem on chromosome seven.
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