Fabiola Tros
French Institute of Health and Medical Research
12 Papers
7 Citations
Fabiola Tros is an academic researcher from French Institute of Health and Medical Research. The author has contributed to research in topics: Staphylococcus aureus & Francisella. The author has an hindex of 6, co-authored 12 publications. Previous affiliations of Fabiola Tros include Paris Descartes University & University of Paris.
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Papers
Intracellular Survival of Staphylococcus aureus in Endothelial Cells: A Matter of Growth or Persistence.
Guillaume Rollin,Guillaume Rollin,Xin Tan,Xin Tan,Fabiola Tros,Fabiola Tros,Marion Dupuis,Marion Dupuis,Xavier Nassif,Xavier Nassif,Xavier Nassif,Alain Charbit,Alain Charbit,Mathieu Coureuil,Mathieu Coureuil +14 more
TL;DR: It is suggested that internalization of S. aureus in endothelial cells triggers its persistence and support the notion that endothelium cells might constitute an intracellular persistence niche responsible for reported relapse of infection after antibiotic therapy.
Importance of branched-chain amino acid utilization in Francisella intracellular adaptation
Gael Gesbert,Elodie Ramond,Elodie Ramond,Fabiola Tros,Fabiola Tros,Julien Dairou,Eric Frapy,Eric Frapy,Monique Barel,Monique Barel,Alain Charbit,Alain Charbit +11 more
TL;DR: The data presented establish the importance of isoleucine utilization for efficient phagosomal escape and cytosolic multiplication of Francisella and suggest that virulent F. tularensis subspecies have lost their branched-chain amino acid biosynthetic pathways and rely exclusively on dedicated uptake systems.
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Chronic Staphylococcus aureus Lung Infection Correlates With Proteogenomic and Metabolic Adaptations Leading to an Increased Intracellular Persistence.
Xin Tan,Mathieu Coureuil,Elodie Ramond,Daniel Euphrasie,Marion Dupuis,Fabiola Tros,Julie Meyer,Ivan Nemazanyy,Cerina Chhuon,Ida Chiara Guerrera,Agnès Ferroni,Isabelle Sermet-Gaudelus,Xavier Nassif,Alain Charbit,Anne Jamet +14 more
TL;DR: The results strongly suggest that the intracellular environment might constitute an important niche of persistence and relapse necessitating adapted antibiotic treatments, and identify the underlying genetic modifications inducing altered protein expression profiles and notable metabolic changes that could constitute therapeutic targets.
A splenic IgM memory subset with antibacterial specificities is sustained from persistent mucosal responses.
Simon Le Gallou,Zhicheng Zhou,Lan Huong Thai,Rémi Fritzen,Alba Verge de los Aires,Jérôme Mégret,Philipp Yu,Daisuke Kitamura,Emmanuelle Bille,Emmanuelle Bille,Fabiola Tros,Xavier Nassif,Xavier Nassif,Alain Charbit,Sandra K. Weller,J.C. Weill,C.A. Reynaud +16 more
TL;DR: It is described here, based on an inducible AID fate-mapping mouse model, that systemic memory B cell subsets, including mainly IgM+ B cells inSpleen, together with IgA+ plasma cells in spleen and bone marrow, are generated in mice in the absence of deliberate immunization.
Transketolase of Staphylococcus aureus in the Control of Master Regulators of Stress Response During Infection.
Xin Tan,Xin Tan,Elodie Ramond,Elodie Ramond,Anne Jamet,Anne Jamet,Jean-Philippe Barnier,Jean-Philippe Barnier,Baptiste Decaux-Tramoni,Baptiste Decaux-Tramoni,Marion Dupuis,Marion Dupuis,Daniel Euphrasie,Daniel Euphrasie,Fabiola Tros,Fabiola Tros,Ivan Nemazanyy,Ivan Nemazanyy,Ivan Nemazanyy,Jason Ziveri,Jason Ziveri,Xavier Nassif,Xavier Nassif,Alain Charbit,Alain Charbit,Mathieu Coureuil,Mathieu Coureuil +26 more
TL;DR: It is shown that inactivation of the unique gene encoding transketolase activity in S. aureus USA300 (∆tkt) led to drastic metabolomic changes, which suggests that TKT -or a functional PPP- strongly influences the ability of S.aureus to proliferate within host cells by modulating key transcriptional regulators.