Fabiola Sinigaglia
University of Eastern Piedmont
89 Papers
766 Citations
Fabiola Sinigaglia is an academic researcher from University of Eastern Piedmont. The author has contributed to research in topics: Platelet & Platelet activation. The author has an hindex of 26, co-authored 89 publications. Previous affiliations of Fabiola Sinigaglia include University of Genoa & University of Turin.
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Papers
Ghrelin and des-acyl ghrelin inhibit cell death in cardiomyocytes and endothelial cells through ERK1/2 and PI 3-kinase/AKT
Gianluca Baldanzi,Nicoletta Filigheddu,Santina Cutrupi,Filomena Catapano,Sara Bonissoni,Alberto Fubini,Daniela Malan,G. Baj,Riccarda Granata,Fabio Broglio,Mauro Papotti,Nicola Surico,Federico Bussolino,Jörgen Isgaard,Romano Deghenghi,Fabiola Sinigaglia,Maria Prat,Giampiero Muccioli,Ezio Ghigo,Andrea Graziani +19 more
TL;DR: These findings provide the first evidence that, independent of its acylation, ghrelin gene product may act as a survival factor directly on the cardiovascular system through binding to a novel, yet to be identified receptor, which is distinct from GHSR-1a.
Ghrelin and Des-Acyl Ghrelin Promote Differentiation and Fusion of C2C12 Skeletal Muscle Cells
Nicoletta Filigheddu,Viola F. Gnocchi,Marco Coscia,Miriam Cappelli,Paolo E. Porporato,Riccardo Taulli,Sara Traini,Gianluca Baldanzi,Federica Chianale,Santina Cutrupi,Elisa Arnoletti,Corrado Ghè,Alberto Fubini,Nicola Surico,Fabiola Sinigaglia,Carola Ponzetto,Giampiero Muccioli,Tiziana Crepaldi,Andrea Graziani +18 more
TL;DR: It is shown that both gh Relin and des-acyl ghrelin stimulate proliferating C2C12 skeletal myoblasts to differentiate and to fuse into multinucleated myotubes in vitro through activation of p38, and that C2 C12 cells do not express GHSR-1a, but they do contain a common high-affinity binding site recognized by both acylated and des
Acylated and unacylated ghrelin impair skeletal muscle atrophy in mice
Paolo E. Porporato,Nicoletta Filigheddu,Simone Reano,Michele Ferrara,Elia Angelino,Viola F. Gnocchi,Flavia Prodam,Giulia Ronchi,Sharmila Fagoonee,Michele Fornaro,Federica Chianale,Gianluca Baldanzi,Nicola Surico,Fabiola Sinigaglia,Isabelle Perroteau,Roy G. Smith,Yuxiang Sun,Stefano Geuna,Andrea Graziani +18 more
TL;DR: It is demonstrated that AG and UnAG act on a common, unidentified receptor to block skeletal muscle atrophy in a GH-independent manner.
A selective role for phosphatidylinositol 3,4,5-trisphosphate in the Gi-dependent activation of platelet Rap1B.
Paolo Lova,Simona Paganini,Emilio Hirsch,Laura Barberis,Matthias P. Wymann,Fabiola Sinigaglia,Cesare Balduini,Mauro Torti +7 more
TL;DR: It is concluded that stimulation of a Gi-dependent signaling pathway causes activation of the small GTPase Rap1B through the action of the PI3K product PtdIns(3,4,5)P3, but not Ptrisphosphate, and that this process may contribute to potentiation of platelet aggregation.
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Benefits from new ADP antagonists as compared with clopidogrel in patients with stable angina or acute coronary syndrome undergoing invasive management: a meta-analysis of randomized trials.
M. Verdoia,Alon Schaffer,Lucia Barbieri,Ettore Cassetti,Raffaele Piccolo,Gennaro Galasso,Paolo Marino,Fabiola Sinigaglia,Giuseppe De Luca +8 more
TL;DR: Present meta-analysis shows that the new ADP antagonists prasugrel, ticagrelor, and cangrelor are associated to significant reduction of mortality, reinfarction, RI, and ST respect to clopidogrel alone, without significant increase in bleeding complications.
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