Fabio Pohl
University of São Paulo
3 Papers
7 Citations
Fabio Pohl is an academic researcher from University of São Paulo. The author has contributed to research in topics: Medicine & Biology. The author has an hindex of 1, co-authored 1 publications.
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Papers
Developmental landscape of human forebrain at a single-cell level identifies early waves of oligodendrogenesis.
David van Bruggen,Fabio Pohl,Christoffer Mattsson Langseth,Petra Kukanja,Hower Lee,Alejandro Mossi Albiach,Mukund Kabbe,Mandy Meijer,Sten Linnarsson,Markus M. Hilscher,Mats Nilsson,Erik Sundström,Gonçalo Castelo-Branco +12 more
TL;DR: Using single-cell RNA sequencing, the authors found evidence of the emergence of a first wave of oligodendrocyte lineage cells as early as post-conception weeks (PCW) 8-10.
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Marked regional glial heterogeneity in the human white matter of the central nervous system
Luise A. Seeker,Nadine Bestard-Cuche,Sarah Jäkel,Nina-Lydia Kazakou,Sunniva M. K. Bøstrand,Alastair M. Kilpatrick,David van Bruggen,Mukund Kabbe,Fabio Pohl,Zahra Moslehi,Neil C. Henderson,Catalina A. Vallejos,Gioele La Manno,Gonçalo Castelo-Branco,Anna Williams +14 more
TL;DR: Using single nucleus RNA sequencing of healthy human post-mortem samples, marked glial heterogeneity is found with tissue region (primary motor cortex, cerebellum, cervical spinal cord), with tissue-specific cell populations of oligodendrocyte precursor cells and astrocytes, and a spinal cord-enriched oligod endocrine type that appears human-specific.
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Molecular alterations in the extracellular matrix in the brains of newborns with congenital Zika syndrome.
Renato S. Aguiar,Renato S. Aguiar,Fabio Pohl,Guilherme Loss de Morais,Fábio C. S. Nogueira,Joseane B. Carvalho,Leticia Guida,Luis W. P. Arge,Adriana Suely de Oliveira Melo,Maria Elisabeth Lopes Moreira,Daniela P. Cunha,Leonardo Henrique Ferreira Gomes,Elyzabeth Avvad Portari,Erika Velasquez,Rafael D. Melani,Paula Pezzuto,Fernanda L. De Castro,Victor Emmanuel Viana Geddes,Alexandra L. Gerber,Girlene S. Azevedo,Bruno L. Schamber-Reis,Alessandro L. Gonçalves,Inácio L.M. Junqueira-de-Azevedo,Milton Y. Nishiyama,Paulo Lee Ho,Alessandra S. Schanoski,Viviane Schuch,Amilcar Tanuri,Leila Chimelli,Zilton Vasconcelos,Gilberto B. Domont,Ana Tereza Ribeiro de Vasconcelos,Helder I. Nakaya +32 more
TL;DR: It is demonstrated that ZIKV-infected neonates showed a reduction in collagen expression and an increase in adhesion factor expression, alterations in the extracellular matrix consistent with the brain defects seen in CZS, and host genes associated with CzS susceptibility are revealed.