Fabio Parmeggiani
Polytechnic University of Milan
122 Papers
741 Citations
Fabio Parmeggiani is an academic researcher from Polytechnic University of Milan. The author has contributed to research in topics: Chemistry & Biocatalysis. The author has an hindex of 29, co-authored 110 publications. Previous affiliations of Fabio Parmeggiani include University of Washington & Fred Hutchinson Cancer Research Center.
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Papers
Exploring the repeat protein universe through computational protein design.
T. J. Brunette,Fabio Parmeggiani,Po-Ssu Huang,Gira Bhabha,Damian C. Ekiert,Susan E. Tsutakawa,Greg L. Hura,Greg L. Hura,John A. Tainer,David Baker +9 more
TL;DR: The results show that existing repeat proteins occupy only a small fraction of the possible repeat protein sequence and structure space and that it is possible to design novel repeat proteins with precisely specified geometries, opening up a wide array of new possibilities for biomolecular engineering.
De novo design of a four-fold symmetric TIM-barrel protein with atomic-level accuracy
Po-Ssu Huang,Kaspar Feldmeier,Fabio Parmeggiani,D. Alejandro Fernández Velasco,Birte Höcker,David Baker +5 more
TL;DR: The computational design of 4-fold symmetrical (β/α)8-barrels guided by geometrical and chemical principles is described, revealing the importance of sidechain-backbone hydrogen bonding for defining the strand register between repeat units.
Synthetic and Therapeutic Applications of Ammonia-lyases and Aminomutases
TL;DR: The discovery and mechanistic investigations of these commercially relevant enzymes are detailed, along with comparisons of their various applications as stand-alone catalysts, components of artificial biosynthetic pathways and biocatalytic or chemoenzymatic cascades, and therapeutic tools for the potential treatment of various pathologies.
Computational design of self-assembling cyclic protein homo-oligomers.
Jorge A. Fallas,George Ueda,William Sheffler,Vanessa Nguyen,Dan E. McNamara,Banumathi Sankaran,Jose Henrique Pereira,Fabio Parmeggiani,T. J. Brunette,Duilio Cascio,Todd R Yeates,Peter H. Zwart,David Baker +12 more
TL;DR: A general approach to design cyclic homo-oligomers that employs a new residue pair transform method for assessing the design ability of a protein-protein interface that is sufficiently rapid to enable systematic enumeration of cyclically docked arrangements of a monomer followed by sequence design of the newly formed interfaces.
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Biosynthesis and Characterization of Copper Nanoparticles Using Shewanella oneidensis: Application for Click Chemistry.
Richard L. Kimber,Edward A. Lewis,Fabio Parmeggiani,Kurt F. Smith,Heath Bagshaw,Toby Starborg,Nimisha Joshi,Adriana I. Figueroa,Gerrit van der Laan,Giannantonio Cibin,Diego Gianolio,Sarah J. Haigh,Richard A. D. Pattrick,Nicholas J. Turner,Jonathan R. Lloyd +14 more
TL;DR: A novel, simple, green biosynthesis method for producing efficient copper nanoparticle catalysts using the metal-reducing bacterium, Shewanella oneidensis, which is not dependent on the Mtr pathway commonly used to reduce other high oxidation state metals in this bacterium is demonstrated.
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