Fabienne Leidel
Friedrich Loeffler Institute
6 Papers
45 Citations
Fabienne Leidel is an academic researcher from Friedrich Loeffler Institute. The author has contributed to research in topics: Scrapie & Bovine spongiform encephalopathy. The author has an hindex of 5, co-authored 6 publications.
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Papers
Anle138b: a novel oligomer modulator for disease-modifying therapy of neurodegenerative diseases such as prion and Parkinson’s disease
Jens Wagner,Sergey Ryazanov,Sergey Ryazanov,Andrei Leonov,Andrei Leonov,Johannes Levin,Song Shi,Felix Schmidt,Catharina Prix,Francisco J Pan-Montojo,Uwe Bertsch,Gerda Mitteregger-Kretzschmar,Markus Geissen,Martin Eiden,Fabienne Leidel,Thomas Hirschberger,Andreas A. Deeg,Julian J. Krauth,Wolfgang Zinth,Paul Tavan,Jens Pilger,Jens Pilger,Markus Zweckstetter,Markus Zweckstetter,Markus Zweckstetter,Tobias Frank,Mathias Bähr,Jochen H. Weishaupt,Manfred Uhr,Henning Urlaub,Henning Urlaub,Ulrike Teichmann,Matthias Samwer,Kai Bötzel,Martin H. Groschup,Hans A. Kretzschmar,Christian Griesinger,Christian Griesinger,Armin Giese +38 more
TL;DR: The findings suggest that pathological oligomers in neurodegenerative diseases share structural features, although the main protein component is disease-specific, indicating that compounds such as anle138b that modulate oligomer formation by targeting structure-dependent epitopes can have a broad spectrum of activity in the treatment of different protein aggregation diseases.
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From high-throughput cell culture screening to mouse model: identification of new inhibitor classes against prion disease.
Markus Geissen,Fabienne Leidel,Martin Eiden,Thomas Hirschberger,Christine Fast,Uwe Bertsch,Paul Tavan,Armin Giese,Hans A. Kretzschmar,Hermann M. Schätzl,Martin H. Groschup +10 more
TL;DR: A cell‐culture screening system is described that allows for the large‐scale analysis of the PrPres inhibitory potential of a library of compounds and the identification of structural motifs leading potent compounds able to cause PrPres clearance at the cellular level.
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A Medicinal Herb Scutellaria lateriflora Inhibits PrP Replication in vitro and Delays the Onset of Prion Disease in Mice
TL;DR: The traditional medicinal herb Scutellaria lateriflora and its natural compounds, the flavonoids baicalein and baicalin, can be considered as promising candidates for the development of new therapeutic drugs against TSEs and other neurodegenerative diseases like Alzheimer's and Parkinson's disease.
Diphenylpyrazole-Derived Compounds Increase Survival Time of Mice after Prion Infection
Fabienne Leidel,Martin Eiden,Markus Geissen,Hans A. Kretzschmar,Armin Giese,Thomas Hirschberger,Paul Tavan,Hermann M. Schätzl,Martin H. Groschup +8 more
TL;DR: A high in vitro efficiency of DPP derivatives against prion infections that was substantiated in vivo for one of these compounds is demonstrated.
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Piperazine derivatives inhibit PrP/PrP(res) propagation in vitro and in vivo.
Fabienne Leidel,Martin Eiden,Markus Geissen,Thomas Hirschberger,Paul Tavan,Armin Giese,Hans A. Kretzschmar,Hermann M. Schätzl,Martin H. Groschup +8 more
TL;DR: A cell based assay was used for the screening of potential aggregation inhibitors of PrP(Sc) propagation in vitro and identified piperazine derivatives as a new inhibitory lead structure, which increased incubation time of scrapie infected mice.
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