Fabian Schmitz
RWTH Aachen University
15 Papers
283 Citations
Fabian Schmitz is an academic researcher from RWTH Aachen University. The author has contributed to research in topics: Stenosis & Calcium metabolism. The author has an hindex of 14, co-authored 15 publications.
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Papers
The amount of calcium-deficient hexagonal hydroxyapatite in aortic valves is influenced by gender and associated with genetic polymorphisms in patients with severe calcific aortic stenosis.
Jan R. Ortlepp,Fabian Schmitz,Vera Mevissen,Stefan Weiss,Jürgen Huster,Richard Dronskowski,G. Langebartels,Rüdiger Autschbach,Klaus Zerres,Christian Weber,Peter Hanrath,Rainer Hoffmann +11 more
TL;DR: Gender and genetic polymorphisms have an impact on the degree of aortic valve calcification, and if certain allele carriers had additionally the rare CCR5 or CTGF allele the level of calcification was higher.
Cardiovascular risk factors in patients with aortic stenosis predict prevalence of coronary artery disease but not of aortic stenosis: an angiographic pair matched case–control study
TL;DR: None of the cardiovascular risk factors was more prevalent in patients with aortic stenosis than in the base control population or in the pair matched control population, however, male sex, hypercholesterolaemia, smoking, diabetes mellitus, and a family history of coronary artery disease were significantly associated with the presence of additional coronary arteries disease in patientswith aorti stenosis.
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The interleukin-6 promoter polymorphism is associated with elevated leukocyte, lymphocyte, and monocyte counts and reduced physical fitness in young healthy smokers
Jan R. Ortlepp,J. Metrikat,Katharina Vesper,Vera Mevissen,Fabian Schmitz,M. Albrecht,P Maya-Pelzer,Peter Hanrath,Christian Weber,Klaus Zerres,Rainer Hoffmann +10 more
TL;DR: Smoking is associated with elevated leukocytes and lymphocytes and with reduced physical fitness, andGene carriers with the interleukin-6 C allele may suffer particularly from cigarette smoking.
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Systemic and local levels of fetuin-A in calcific aortic valve stenosis.
Jens J. Kaden,Jochen O. Reinöhl,Birgit Blesch,Martina Brueckmann,Dariusch Haghi,Martin Borggrefe,Fabian Schmitz,Sebastian Klomfass,Manuela Pillich,Jan R. Ortlepp +9 more
TL;DR: The data suggest a role of fetuin-A in the pathogenesis calcific aortic valve stenosis independently of the renal function and support the concept that mechanisms of calcium homeostasis are involved in the development of calcificAortic stenosis.
Additive effects of the chemokine receptor 2, vitamin D receptor, interleukin-6 polymorphisms and cardiovascular risk factors on the prevalence of myocardial infarction in patients below 65 years.
Jan R. Ortlepp,Constanze Krantz,Melanie Kimmel,Alexei von Korff,Katharina Vesper,Fabian Schmitz,Vera Mevissen,Uwe Janssens,Andreas Franke,Peter Hanrath,Klaus Zerres,Rainer Hoffmann +11 more
TL;DR: Certain GRF might have additive but small effects on the disposition for MI before the age of 65, possibly indicating a mechanism of aging rather than a purely genetic determined entity.
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