F Wandrer
Hannover Medical School
18 Papers
15 Citations
F Wandrer is an academic researcher from Hannover Medical School. The author has contributed to research in topics: Liver injury & Cirrhosis. The author has an hindex of 7, co-authored 17 publications.
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Papers
TNF-Receptor-1 inhibition reduces liver steatosis, hepatocellular injury and fibrosis in NAFLD mice.
F Wandrer,Stephanie Liebig,Silke Marhenke,Arndt Vogel,Katharina John,Michael P. Manns,Andreas Teufel,Timo Itzel,Thomas Longerich,Olaf Maier,Roman Fischer,Roland E. Kontermann,Klaus Pfizenmaier,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff,Heike Bantel +15 more
TL;DR: The therapeutic effects of a novel antibody, which selectively inhibits TNFR1 while retaining protective TNFR2 signaling in a high-fat diet mouse model of NAFLD, suggest selectiveTNFR1 inhibition as a promising approach forNAFLD treatment.
Senescence mirrors the extent of liver fibrosis in chronic hepatitis C virus infection.
F Wandrer,B. Han,Stephanie Liebig,Jerome Schlue,Michael P. Manns,Klaus Schulze-Osthoff,Heike Bantel +6 more
TL;DR: A mouse model has been developed that simulates the dynamic response of the immune system to viral infection and shows clear patterns of inflammation and cell death that are consistent with those seen in patients with chronic viral hepatitis.
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miR-223 represents a biomarker in acute and chronic liver injury
Florian Schueller,Sanchari Roy,Sven H. Loosen,Jan Alder,Christiane Koppe,Anne T. Schneider,F Wandrer,Heike Bantel,Mihael Vucur,Qing-Sheng Mi,Christian Trautwein,Tom Luedde,Christoph Roderburg +12 more
TL;DR: In acute and chronic models, hepatic miR-223 up-regulation was restricted to hepatocytes and correlated with degree of liver injury and hepatic cell death as well as in liver samples from patients with ALF or liver cirrhosis.
36
Ethanol sensitizes hepatocytes for TGF-β-triggered apoptosis.
H Gaitantzi,Christoph Meyer,Pia Rakoczy,Pia Rakoczy,Maria Thomas,Kristin Wahl,F Wandrer,Heike Bantel,Hamed Alborzinia,Stefan Wölfl,Sabrina Ehnert,Andreas K. Nussler,Ina Bergheim,Loredana Ciuclan,Matthias P. Ebert,Katja Breitkopf-Heinlein,Steven Dooley +16 more
TL;DR: Evidence is given that ethanol directly leads to a boost of TGF-β’s pro-apoptotic function in hepatocytes, which may have implications for patients with chronic alcoholic liver disease.
BH3-only protein expression determines hepatocellular carcinoma response to sorafenib-based treatment.
Stephanie Busche,Katharina John,F Wandrer,Florian W. R. Vondran,Ulrich Lehmann,Heiner Wedemeyer,Frank Essmann,Klaus Schulze-Osthoff,Klaus Schulze-Osthoff,Heike Bantel +9 more
TL;DR: In this article, the authors investigated whether the sorafenib response could be enhanced by combination with pro-apoptotic agents, such as TNF-related apoptosis-inducing ligand (TRAIL) or the BH3-mimetic ABT-737, which target the death receptor and mitochondrial pathway of apoptosis.