F. U. Schade
20 Papers
273 Citations
F. U. Schade is an academic researcher. The author has contributed to research in topics: Whole blood & Tumor necrosis factor alpha. The author has an hindex of 11, co-authored 20 publications.
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Papers
Endotoxin tolerance in rats: expression of TNF-alpha, IL-6, IL-10, VCAM-1 AND HSP 70 in lung and liver during endotoxin shock.
Sascha Flohé,E. Dominguez Fernandez,Marianela Aguirre Ackermann,T. Hirsch,Jochen Börgermann,F. U. Schade +5 more
TL;DR: The presented data show that endotoxin tolerance is reflected by a reduced cytokine expression in lung and liver in vivo, while levels of expression of the adhesion molecule VCAM-1 and the stress protein HSP 70 do not appear to be changed by endotoxinolerance.
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The extent of traumatic damage determines a graded depression of the endotoxin responsiveness of peripheral blood mononuclear cells from patients with blunt injuries.
Matthias Majetschak,R. Flach,Ernst Kreuzfelder,Jennissen,T. Heukamp,Neudeck F,K. P. Schmit-Neuerburg,Udo Obertacke,F. U. Schade +8 more
TL;DR: The endotoxin responsiveness of peripheral blood mononuclear cells displays a functional marker of the anatomically defined severity of injury and gives insights into the regulation of immunocyte function after severe blunt trauma.
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Influence of granulocyte-macrophage colony-stimulating factor (GM-CSF) on whole blood endotoxin responsiveness following trauma, cardiopulmonary bypass, and severe sepsis.
Sascha Flohé,Jochen Börgermann,Fernández Emilio Domínguez,Matthias Majetschak,Lucy Lim,Ernst Kreuzfelder,Udo Obertacke,Dieter Nast-Kolb,F. U. Schade +8 more
TL;DR: Hyporesponsiveness of whole blood induced by trauma, sepsis, or cardiac surgery is not irreversible but can be, at least in vitro, overridden by the immunostimulating compound GM-CSF.
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Regulation of whole blood tumor necrosis factor production upon endotoxin stimulation after severe blunt trauma.
Matthias Majetschak,R. Flach,T. Heukamp,V. Jennissen,Udo Obertacke,F. Neudeck,K. P. Schmit-Neuerburg,F. U. Schade +7 more
TL;DR: Major trauma leads to the appearance of a circulating inhibitory activity for TNF synthesis that may potentially contribute to an anti-inflammatory response in patients with multiple trauma.
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Effects of antimicrobial agents on spontaneous and endotoxin-induced cytokine release of human peripheral blood mononuclear cells
Ulrich Krehmeier,Mark Bardenheuer,Gregor Voggenreiter,Udo Obertacke,F. U. Schade,Matthias Majetschak +5 more
TL;DR: It is concluded that, at present, the direct immunological effects of antibiotics should be interpreted carefully with regard to the experimental conditions, and regardless of the therapeutic implications.
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