F. T. Hatch
Lawrence Livermore National Laboratory
12 Papers
893 Citations
F. T. Hatch is an academic researcher from Lawrence Livermore National Laboratory. The author has contributed to research in topics: Ames test & 2-Amino-1-methyl-6-phenylimidazo(4,5-b)pyridine. The author has an hindex of 11, co-authored 12 publications.
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Papers
The isolation and identification of a new mutagen from fried ground beef: 2-amino-1-methyl-6-phenylimidazo[4,5-b]pyridine (PhIP)
James S. Felton,Mark G. Knize,Nancy H. Shen,P.R. Lewis,B.D. Andresen,James A. Happe,F. T. Hatch +6 more
TL;DR: High-resolution mass spectrometry supports the structure, 2-amino-1-methyl-6-phenyl-imidazo[4,5-b]pyridine (PhIP), for the new mutagen, which is the most abundant mutagenic compound by mass in fried beef.
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Identification of the mutagens in cooked beef.
James S. Felton,Mark G. Knize,Nancy H. Shen,Brian D. Andresen,Leonard F. Bjeldanes,F. T. Hatch +5 more
TL;DR: The PhIP, which contributes the highest mass content to the cooked meat, but has the lowest mutagenic potency, might ultimately make a significant contribution to the carcinogenicity.
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Isolation and characterization of new mutagens from fried ground beef.
James S. Felton,Mark G. Knize,C. Wood,B. J. Wuebbles,Susan K. Healy,Daniel H. Stuermer,Leonard F. Bjeldanes,B. J. Kimble,F. T. Hatch +8 more
TL;DR: Frying of ground beef at 250 degrees C results in the formation of a series of mutagenic heterocyclic amines, possibly as many as 10 distinct compounds which are separated by aqueous/acid extraction from the beef, XAD adsorption, acid/neutral/base-liquid/liquid extraction, preparative reverse phase h.p.l.c.
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Quantitative structure-activity relationships of heterocyclic amine mutagens formed during the cooking of food.
TL;DR: Structural parameters that appeared relevant to determining potency were selected for 38 AlAs and 23 amino‐carbolines and may influence mutagenic potency in the following ways.
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Structural and quantum chemical factors affecting mutagenic potency of aminoimidazo-azaarenes.
TL;DR: Although this study raises several intriguing issues relating mutagenicity to chemical properties, further study will be required to determine the plausibility of the nitrenium ion as the ultimate mutagen for binding to DNA.
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