This study aimed to (1) characterize the variations in serum fructosamine across trimesters and according to pre-pregnancy BMI (ppBMI), and (2) examine associations between fructosamine and adiposity/metabolic markers (ppBMI, first-trimester adiposity, leptin, glucose homeostasis, and inflammation measurements) during pregnancy. Serum fructosamine, albumin, fasting glucose and insulin, leptin, adiponectin, interleukin-6 (IL-6), and C-reactive protein (CRP) concentrations were measured at each trimester. In the first trimester, subcutaneous (SAT) and visceral (VAT) adipose tissue thicknesses were estimated by ultrasound. In the 101 healthy pregnant individuals included (age: 32.2 ± 3.5 y.o.; ppBMI: 25.5 ± 5.5 kg/m2), fructosamine concentrations decreased during pregnancy whereas albumin-corrected fructosamine concentrations increased (p < 0.0001 for both). Notably, fructosamine concentrations were inversely associated with ppBMI, first-trimester SAT, VAT, and leptin (r = −0.55, r = −0.61, r = −0.48, r = −0.47, respectively; p < 0.0001 for all), first-trimester fasting insulin and HOMA-IR (r = −0.46, r = −0.46; p < 0.0001 for both), and first-trimester IL-6 (r = −0.38, p < 0.01). However, once corrected for albumin, most of the correlations lost strength. Once adjusted for ppBMI, fructosamine concentrations were positively associated with third-trimester fasting glucose and CRP (r = 0.24, r = 0.27; p < 0.05 for both). In conclusion, serum fructosamine is inversely associated with adiposity before and during pregnancy, with markers of glucose homeostasis and inflammation, but the latter associations are partially influenced by albumin concentrations and ppBMI.

https://www.mdpi.com/2072-6643/14/19/3999/pdf?version=1664263275

Trimester-Specific Serum Fructosamine in Association with Abdominal Adiposity, Insulin Resistance, and Inflammation in Healthy Pregnant Individuals

Die aktuelle Stoffwechselsituation wird in Selbst- oder arztlicher Kontrolle mit ein- oder mehrmaligen Blutglukosebestimmungen pro Tag in Abhangigkeit vom Tagesablauf des Patienten erfast Der Nachweis oder die Bestimmung der Uringlukose haben durch die Selbstkontrolle mit Blutglukosebestimmungen an Bedeutung eingebust, konnen aber besonders bei Typ-II-Diabetikern mit bekannter Nierenschwelle einen ausreichenden Uberblick verschaffen Das glykierte Hamoglobin (HbA1) ist zur Einschatzung der mittleren integrativen Glykamielage 6–8 Wochen vor der Blutentnahme bereits fest im Kontrollsystem etabliert, wahrend die Indikationen fur das nur 2–3 Wochen zuruckreichende Fruktosamin eingeschrankt sind Die lebenslange Verlaufskontrolle erfordert eine Verbesserung der Standardisierung der glykierten Eiweise und insgesamt intensive Bemuhungen um die Qualitatssicherung

Bewertung verschiedener labordiagnostischer Methoden zur Therapieführung und Verlaufskontrolle des Diabetes mellitus

Genetic studies of cardiometabolic traits

Detetermination of reference values for a colorimetric fructosamine assay

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Detetermination of reference values for a colorimetric fructosamine assay