F. Owen
University of Manchester
34 Papers
682 Citations
F. Owen is an academic researcher from University of Manchester. The author has contributed to research in topics: Dementia & Apolipoprotein E. The author has an hindex of 25, co-authored 34 publications. Previous affiliations of F. Owen include University of Leicester.
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Papers
Association of missense and 5′-splice-site mutations in tau with the inherited dementia FTDP-17
Mike Hutton,Corinne Lendon,Patrizia Rizzu,Matt Baker,Susanne Froelich,Susanne Froelich,Henry Houlden,Stuart Pickering-Brown,Sumitra Chakraverty,Adrian M. Isaacs,Andrew Grover,J. Hackett,Jennifer Adamson,Sarah Lincoln,Dennis W. Dickson,Peter Davies,Ronald C. Petersen,M. Stevens,E. De Graaff,E. Wauters,J. Van Baren,M. Hillebrand,Marijke Joosse,J. M. Kwon,Petra Nowotny,Lien Kuei Che,Joanne Norton,John C. Morris,L. A. Reed,John Q. Trojanowski,Hans Basun,Lars Lannfelt,M. Neystat,Stanley Fahn,Frances Dark,Tony Tannenberg,Peter R. Dodd,Nicholas K. Hayward,John B.J. Kwok,Peter R. Schofield,Athena Andreadis,Julie S. Snowden,David Craufurd,David Neary,F. Owen,Ben A. Oostra,John Hardy,Alison Goate,J. C. van Swieten,David M. A. Mann,Timothy Lynch,Peter Heutink +51 more
TL;DR: In this paper, the authors sequenced tau in FTDP-17 families and identified three missense mutations (G272V, P301L and R406W) and three mutations in the 5' splice site of exon in
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Inherited prion disease with 144 base pair gene insertion: 2. clinical and pathological features
John Collinge,Jeremy P Brown,J. Hardy,Michael Mullan,Martin N. Rossor,Harry F. Baker,T. J. Crow,R. Lofthouse,Mark Poulter,Rosalind M. Ridley,F. Owen,C. Bennett,G. Dunn,A. E. Harding,Niall Quinn,B. Doshi,G. W. Roberts,M. Honavar,I. Janota,Peter L. Lantos +19 more
TL;DR: The phenotype of inherited prion disease (PrP 144 bp insertion) is described, a large family with autosomal dominant segregation of presenile dementia, and other neurological and behavioural features is described.
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Apolipoprotein E epsilon 2 allele promotes longevity and protects patients with Down's syndrome from dementia.
M C Royston,David M. A. Mann,Stuart Pickering-Brown,F. Owen,Robert H. Perry,R Raghavan,C Khin-Nu,Stephen P. Tyrer,Kenneth Day,Richard Crook +9 more
TL;DR: It is shown, in a series of clinically assessed individuals with Down's syndrome, that the epsilon 2 allele of ApoE is associated with both longevity and the absence of clinical evidence of dementia, and shows that the clinical phenotype of Down’s syndrome can be modulated by genes on chromosomes other than chromosome 21.
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A dementing illness associated with a novel insertion in the prion protein gene.
TL;DR: The insertion which is in frame encodes 9 extra octapeptide repeat sequences in addition to the 5 repeats normally present and represents the largest insertion so far detected in the PrP gene.
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[3H]R05-4864 and [3H]flunitrazepam binding in kainate-lesioned rat striatum and in temporal cortex of brains from patients with senile dementia of the Alzheimer type.
TL;DR: It is suggested that the poor binding characteristics of [3H]R05-4864 in human brain samples may limit its usefulness in assessing gliosis.
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