F. Leitner
Syracuse University
12 Papers
259 Citations
F. Leitner is an academic researcher from Syracuse University. The author has contributed to research in topics: Cephalosporin & Cephaloridine. The author has an hindex of 9, co-authored 12 publications.
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Papers
BMY 28100, a new oral cephalosporin.
F. Leitner,T. A. Pursiano,R. E. Buck,Y H Tsai,D R Chisholm,M. Misiek,J V Desiderio,R E Kessler +7 more
TL;DR: BMY 28100, a new oral cephalosporin with a (Z)-propenyl side chain at the 3 position and a p-hydroxyphenylglycyl substituent at the 7 position, was evaluated in comparison with cefaclor and cephalexin and, when appropriate, ampicillin and vancomycin.
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Laboratory Evaluation of BL-S786, a Cephalosporin with Broad-Spectrum Antibacterial Activity
F. Leitner,M. Misiek,T. A. Pursiano,R. E. Buck,D R Chisholm,R. G. Deregis,Y. H. Tsai,K. E. Price +7 more
TL;DR: Although BL-S786 was generally less active than the control cephalosporins against gram-positive pathogens, it inhibited their growth at concentrations that should readily be achieved in humans after standard parenteral dosage.
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BL-S 640, a Cephalosporin with a Broad Spectrum of Antibacterial Activity: Properties In Vitro
TL;DR: BL-S 640 was an effective bactericidal agent for strains of various species of Enterobacteriaceae and its antibacterial spectrum included strains ofEnterobacter, Proteus morganii, P. rettgeri, and Providencia stuartii, species generally resistant to the other cephalosporins.
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BL-S640, a Cephalosporin with a Broad Spectrum of Antibacterial Activity: Bioavailability and Therapeutic Properties in Rodents
TL;DR: BL-S 640 was highly effective in the treatment of mice infected systemically with a variety of pathogenic bacteria, its therapeutic efficacy in comparison with that of other cephalosporins being frequently in excess of what would have been predicted on the basis of comparative activities in vitro.
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Bactericidal activity of cefadroxil, cephalexin, and cephradine in an in vitro pharmacokinetic model.
TL;DR: Analysis of the results suggest that the pharmocokinetic properties of an antibiotic affect its activity in the blood stream, provided the susceptibility of the infecting organism is concentration-dependent within the range of drug concentration occurring in serum.
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