5 Papers
6 Citations
F Bene is an academic researcher from Queen Mary University of London. The author has contributed to research in topics: Early Inflammatory Arthritis & Rheumatoid arthritis. The author has an hindex of 3, co-authored 5 publications.
Chat about Author
Papers
Synovial cellular and molecular signatures stratify clinical response to csDMARD therapy and predict radiographic progression in early rheumatoid arthritis patients
Frances Humby,Myles Lewis,Nandhini Ramamoorthi,Jason A. Hackney,Michael R. Barnes,Michele Bombardieri,A. Francesca Setiadi,Stephen Kelly,F Bene,M DiCicco,Sudeh Riahi,V. Rocher,Nora Ng,Ilias Lazarou,Rebecca Hands,Désirée van der Heijde,Robert Landewé,Annette H M van der Helm-van Mil,Alberto Cauli,Iain B. McInnes,Christopher D. Buckley,Ernest Choy,Peter C. Taylor,Michael J. Townsend,Costantino Pitzalis +24 more
TL;DR: At disease presentation, prior to pathology modulation by therapy, the presence of specific cellular/molecular synovial signatures that delineate disease severity/progression and therapeutic response may pave the way to more precise definition of RA taxonomy, therapeutic targeting and improved outcomes.
266
Synovial tissue signatures enhance clinical classification and prognostic/treatment response algorithms in early inflammatory arthritis and predict requirement for subsequent biological therapy: results from the pathobiology of early arthritis cohort (PEAC)
Gloria Lliso-Ribera,Frances Humby,Myles Lewis,Alessandra Nerviani,Daniele Mauro,Felice Rivellese,Stephen Kelly,Rebecca Hands,F Bene,Nandhini Ramamoorthi,Jason A. Hackney,Alberto Cauli,Ernest Choy,Andrew Filer,Peter C. Taylor,Iain B. McInnes,Michael J. Townsend,Costantino Pitzalis +17 more
TL;DR: The capacity to refine early clinical classification criteria through synovial pathobiological markers offers the potential to predict disease outcome and stratify therapeutic intervention to patients most in need.
91
OP0040 Synovial cell infiltration in acpa-ve patients displays similar signatures to other seronegative inflammatory arthritis. results from the pathobiology of early arthritis cohort (PEAC)
Gloria Lliso-Ribera,Frances Humby,Alessandra Nerviani,Marie-Astrid Boutet,Stephen Kelly,Michele Bombardieri,Myles Lewis,Rebecca Hands,V. Rocher,F Bene,Christopher D. Buckley,Peter C. Taylor,Iain B. McInnes,C. Pitzalis +13 more
TL;DR: This study examines in a cohort of therapy naïve, early inflammatory arthritis patients whether ACPA-ve RA can be defined at disease initiation according to synovial pathobiological signatures and suggests shared pathophysiological mechanisms between PsA and ACPA -ve RA and support a role for future refinement of diagnosis.
THU0100 In early inflammatory arthritis a lymphoid pathotype signficantly associates with requirement for biologic therapy at 12 months follow up: results from the pathobiology of early arthritis cohort (PEAC)
Gloria Lliso-Ribera,Frances Humby,S Kelly,Michele Bombardieri,Myles Lewis,Rebecca Hands,V. Rocher,F Bene,Alessandra Nerviani,C Buckely,Peter C. Taylor,Iain B. McInnes,C. Pitzalis +12 more
TL;DR: Results demonstrate that in an early inflammatory arthritis cohort a lymphoid pathotype significantly associates with higher disease activity at baseline, sero positivity for RF and ACPA and a requirement for more aggressive therapy at 12 month, and suggests a role as a prognostic biomarker facilitating early stratification of aggressive therapeutic intervention.
1
Anti-TNF-alpha agents and endothelial function in rheumatoid arthritis: a systematic review and meta-analysis.
Francesco Ursini,Francesco Ursini,Christian Leporini,F Bene,Salvatore D'Angelo,Daniele Mauro,Emilio Russo,Giovambattista De Sarro,Ignazio Olivieri,Costantino Pitzalis,Myles Lewis,Rosa Daniela Grembiale +11 more
TL;DR: The meta-analysis suggests that anti-TNF-α treatment may improve endothelial function in RA patients, although limited by the methodological quality of the included studies.