This report reviews how to set up a laser Doppler perfusion imaging system intended for visualization of skin blood perfusion, capture images and evaluate the results obtained. A brief summary of related papers published in the literature within the areas of skin irritant and allergy patch testing, microdialysis and skin tumour circulation is presented, as well as early applications within other fields such as diabetology, wound healing and microvascular research.

Guidelines for visualization of cutaneous blood flow by laser Doppler perfusion imaging: A report from the Standardization Group of the European Society of Contact Dermatitis based upon the HIRELADO European community project

BACKGROUND Laser Dopplers can be useful in determining the relative amount of blood flowing through superficial skin. These instruments may be useful in assessing blood flow in healing wounds, flaps, and grafts.



OBJECTIVE To review the theory and types of laser Dopplers available.



METHODS This work includes a review of the literature.



RESULTS Laser Dopplers potentially have a broad range of applications in dermatologic surgery and dermatology. Because laser Dopplers can quantify blood flow, the course of wound healing over time can be studied; however, for predicting viability of skin flaps and grafts, laser Dopplers have not been able to supplant clinical assessment.



CONCLUSION Laser Dopplers provide an additional means of assessing superficial blood flow in the skin. This blood flow, which can be quantified, may be useful in studying wound and flap and graft healing.

Laser Dopplers to determine cutaneous blood flow

Ischemic preconditioning of the myocardium with repeated brief periods of ischemia and reperfusion prior to prolonged ischemia significantly reduces subsequent myocardial infarction. Following ischemic preconditioning, two “windows of opportunity” (early and late) exist, during which time prolonged

Acute ischemic preconditioning of skeletal muscle prior to flap elevation augments muscle-flap survival

Metabolic mapping with bioluminescence: basic and clinical relevance.

Background:

Skin-sparing mastectomy (SSM) is a new technique being used in a variety of clinical settings This article reviews the published data on SSM to establish its current role in clinical practice



Methods:

A Medline search was carried out using the key words ‘skin-sparing mastectomy’ to identify English-language articles published between 1990 and 2004 and further material referenced in these publications



Results:

SSM is most commonly used for surgical prophylaxis and to treat in situ and early invasive disease in patients who request immediate breast reconstruction SSM and non-SSM result in similar surgical and oncological outcomes, but skin flap ischaemia is more common after SSM and is associated with a range of risk factors, including smoking



Conclusion:

SSM has become an established procedure in breast surgery, but there is a lack of prospective data on which to make evidence-based decisions about its use in individual patients Copyright © 2006 British Journal of Surgery Society Ltd Published by John Wiley & Sons, Ltd

Skin‐sparing mastectomy

Perfusion imaging of skin island flap blood flow by a scanning laser-Doppler technique

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Perfusion imaging of skin island flap blood flow by a scanning laser-Doppler technique