F.A. Ogunbona
Obafemi Awolowo University
21 Papers
163 Citations
F.A. Ogunbona is an academic researcher from Obafemi Awolowo University. The author has contributed to research in topics: Pharmacokinetics & Detection limit. The author has an hindex of 10, co-authored 21 publications.
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Papers
Pharmacokinetics of quinine in African patients with acute falciparum malaria.
TL;DR: The present data suggest that malaria parasites in African patients are still very sensitive to quinine and that the current dosage of qu inine is effective for the treatment of acute falciparum malaria in African Patients without augmenting therapy with any other drug such as tetracycline or sulphadoxine-pyrimethamine.
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Pharmacokinetics and bioavailability of drotaverine in humans
TL;DR: It is suggested that the high variation in the bioavailability of drotaverine HCl after oral administration may result in significant interindividual differences in therapeutic response.
31
Column liquid chromatographic analysis of quinine in human plasma, saliva and urine
TL;DR: A new simple, selective and reproducible high-performance liquid chromatographic method for the determination of quinine in plasma, saliva and urine is described, which was well resolved from its major metabolite, 3-hydroxyquinine, and the internal standard, primaquine.
23
Pharmacokinetic aspects of chloroquine-induced pruritus: influence of dose and evidence for varied extent of metabolism of the drug.
Cyprian O. Onyeji,F.A. Ogunbona +1 more
TL;DR: There might be a decreased metabolism of CQ in subjects susceptible to CQ-induced pruritus following ingestion of a therapeutic dose, and the extent of metabolism ofCQ in this group may be influenced by the dose of the drug.
23
Polymorphic oxidative metabolism of proguanil in a Nigerian population.
TL;DR: The study further supports previous studies that proguanil can be used as an alternative probe to phenotype for CYP2C19 activity and demonstrates enormous inter-individual differences in the urinary proguanIL/cycloguanil ratios.
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