3 Papers
4 Citations
Ewa Krol is an academic researcher from University of Southern California. The author has contributed to research in topics: Amlodipine & Ryanodine receptor. The author has an hindex of 3, co-authored 3 publications.
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Papers
Effect of amlodipine therapy on the monoclonal antibody 3G8-induced calcium signal in polymorphonuclear leukocytes of hemodialysis patients
TL;DR: It is concluded that chronic renal failure is associated with deranged calcium homeostasis of PMNLs which causes abnormalities in the function of Fcγ RIII receptors and consequently results in impaired phagocytosis and therapy with a calcium channel blocker can reverse all these derangements in metabolism and function ofPMNLs.
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Mechanisms through which high glucose concentration raises [Ca2+]i in renal proximal tubular cells
TL;DR: The results are consistent with the formulation that the osmotic activity (cell shrinkage) of the high glucose concentration may activate a stretch receptor with subsequent stimulation of various cellular pathways including G protein(s), cAMP-protein kinase A and phospholipase C systems and calcium channels.
Amlodipine reverses the elevation in [Ca2+]i and the impairment of phagocytosis in PMNLs of NIDDM patients
TL;DR: The results show that the elevation in basal levels of [Ca2+]i of the PMNLs is associated with down-regulation of the mRNA of their Fc gamma RIII receptors, which is at least, in part, responsible for the impaired phagocytosis.