Eve McCutchen
University of Alabama at Birmingham
4 Papers
29 Citations
Eve McCutchen is an academic researcher from University of Alabama at Birmingham. The author has contributed to research in topics: Long-term depression & Cholinergic. The author has an hindex of 4, co-authored 4 publications.
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Papers
Coexistence of Muscarinic Long-Term Depression With Electrically Induced Long-Term Potentiation and Depression at CA3–CA1 Synapses
TL;DR: The data demonstrate that mLTD can coexist with electrically induced forms of synaptic plasticity and support the hypothesis thatmLTD is one of the mechanisms by which the cholinergic system modulates hippocampal function.
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Coactivation of M1 Muscarinic and α1 Adrenergic Receptors Stimulates Extracellular Signal-Regulated Protein Kinase and Induces Long-Term Depression at CA3–CA1 Synapses in Rat Hippocampus
Cary L. Scheiderer,Caroline C. Smith,Eve McCutchen,Portia A. McCoy,Erin E. Thacker,Krystyna Kolasa,Lynn E. Dobrunz,Lori L. McMahon +7 more
TL;DR: This study tested the hypothesis that mLTD and NE LTD are independent forms of LTD, yet require activation of a common Gαq-coupled signaling pathway for their induction, and investigated the net effect of coactivation of M1 and α1 receptors on the magnitude of LTD induced.
Tau-mediated NMDA receptor impairment underlies dysfunction of a selectively vulnerable network in a mouse model of frontotemporal dementia.
Brian A. Warmus,Dheepa R. Sekar,Eve McCutchen,Gerard D. Schellenberg,Rosalinda C. Roberts,Lori L. McMahon,Erik D. Roberson +6 more
TL;DR: It is indicated that NMDAR hypofunction critically contributes to FTD-associated behavioral and electrophysiological alterations and that this process can be therapeutically targeted by a Food and Drug Administration–approved drug.
Sympathetic Sprouting Drives Hippocampal Cholinergic Reinnervation That Prevents Loss of a Muscarinic Receptor-Dependent Long-Term Depression at CA3–CA1 Synapses
Cary L. Scheiderer,Eve McCutchen,Erin E. Thacker,Krystyna Kolasa,Matthew K. Ward,Dee S. Parsons,Lindy E. Harrell,Lynn E. Dobrunz,Lori L. McMahon +8 more
TL;DR: A novel phenomenon is discovered whereby the autonomic and central nervous systems experience structural rearrangement to replace lost cholinergic innervation in hippocampus, with the consequence of preserving a form of LTD that would otherwise be lost as a result of Cholinergic degeneration.