Eva Dazert
University of Basel
14 Papers
64 Citations
Eva Dazert is an academic researcher from University of Basel. The author has contributed to research in topics: Biology & PI3K/AKT/mTOR pathway. The author has an hindex of 7, co-authored 9 publications. Previous affiliations of Eva Dazert include University Hospital of Basel.
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Papers
mTORC2 Promotes Tumorigenesis via Lipid Synthesis.
Yakir Guri,Marco Colombi,Eva Dazert,Sravanth K. Hindupur,Jason Roszik,Suzette Moes,Paul Jenoe,Markus H. Heim,Isabelle Riezman,Howard Riezman,Michael N. Hall +10 more
TL;DR: An mTOR-driven mouse model that displays hepatosteatosis progressing to hepatocellular carcinoma (HCC) is described, revealing that hepatic mTORC2 promotes de novo fatty acid and lipid synthesis, leading to steatosis and tumor development.
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Integrative proteogenomic characterization of hepatocellular carcinoma across etiologies and stages
Charlotte K.Y. Ng,Eva Dazert,Tuyana Boldanova,Mairene Coto-Llerena,Sandro Nuciforo,Caner Ercan,Aleksei Suslov,Marie-Anne Meier,Thomas Bock,Alexander Schmidt,Sylvia Ketterer,Xueya Wang,Stefan Wieland,Matthias S. Matter,Marco Colombi,Salvatore Piscuoglio,L. Terracciano,Michael N. Hall,Markus H. Heim +18 more
TL;DR: In this article , an integrated proteogenomic analysis of hepatocellular carcinoma (HCC) across clinical stages and etiologies is presented, revealing the major pathways altered in the (phospho)proteome.
Arginine reprograms metabolism in liver cancer via RBM39
Dirk Mossmann,Christoph Müller,Sujin Park,Brendan Ryback,Marco Colombi,Nathalie Ritter,Diana Weissenberger,Eva Dazert,Mairene Coto-Llerena,Sandro Nuciforo,L. Blukacz,Caner Ercan,Veronica Jimenez,Salvatore Piscuoglio,Fatima Bosch,L. Terracciano,Uwe Sauer,Markus H. Heim,Michael N. Hall +18 more
TL;DR: Arginine levels are elevated in murine and patient hepatocellular carcinoma (HCC), despite reduced expression of arginine synthesis genes, indicating a positive feedback loop to sustain high arkinine levels and oncogenic metabolism.
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LATS1 but not LATS2 represses autophagy by a kinase-independent scaffold function.
Fengyuan Tang,Ruize Gao,Beena Jeevan-Raj,Christof B. Wyss,Ravi Kiran Reddy Kalathur,Salvatore Piscuoglio,Charlotte K.Y. Ng,Sravanth K. Hindupur,Sandro Nuciforo,Eva Dazert,Thomas Bock,Shuang Song,David Buechel,Marco Francesco Morini,Alexander Hergovich,Patrick Matthias,Dae-Sik Lim,Luigi Terracciano,Markus H. Heim,Michael N. Hall,Gerhard Christofori +20 more
TL;DR: It is shown that LATS1, but not LATS2, negatively regulates autophagy by promoting Beclin1 ubiquitination, which restricts lethal autophapy induced by sorafenib treatment in cancer cells.
Acquisition of an immunosuppressive protumorigenic macrophage phenotype depending on c-Jun phosphorylation
Simona Hefetz-Sela,Ilan Stein,Yair Klieger,Rinnat M. Porat,Moshe Sade-Feldman,Farid Zreik,Arnon Nagler,Orit Pappo,Luca Quagliata,Eva Dazert,Robert Eferl,Luigi Terracciano,Erwin F. Wagner,Yinon Ben-Neriah,Michal Baniyash,Eli Pikarsky +15 more
TL;DR: It is reported that germ-line absence of c- Jun N-terminal phosphorylation at serines 63 and 73 impedes inflammation-associated hepatocarcinogenesis, yet deleting c-Jun only in hepatocytes does not inhibit hepatocellular carcinoma (HCC) formation, and the possibility that targeting immune checkpoints could be effective for tumor prevention in chronic inflammatory diseases is raised.
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