Eva Darai
Karolinska Institutet
5 Papers
33 Citations
Eva Darai is an academic researcher from Karolinska Institutet. The author has contributed to research in topics: Biology & Gene. The author has an hindex of 5, co-authored 5 publications.
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Papers
LIM domains-containing protein 1 (LIMD1), a tumor suppressor encoded at chromosome 3p21.3, binds pRB and represses E2F-driven transcription
Tyson V. Sharp,Fernando Munoz,Dimitra Bourboulia,Nadege Presneau,Eva Darai,Hsei-Wei Wang,Mark Cannon,D.N. Butcher,Andrew G. Nicholson,George Klein,Stephan Imreh,Chris Boshoff +11 more
TL;DR: The data indicate that LIMD1 is a tumor-suppressor gene, the protein product of which functionally interacts with pRB and the loss of which promotes lung carcinogenesis.
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Consistent downregulation of human lactoferrin gene, in the common eliminated region 1 on 3p21.3, following tumor growth in severe combined immunodeficient (SCID) mice
Ying Yang,Jingfeng Li,Anna Szeles,Marta P. Imreh,Maria Kost-Alimova,Hajnalka Kiss,Irina Kholodnyuk,Ludmilla Fedorova,Eva Darai,George Klein,Stefan Imreh +10 more
TL;DR: Promoter methylation and/or rearrangement of the insertion site may be responsible for human LF downregulation in mouse fibrosarcoma derived tumors.
21
Evolutionarily plastic regions at human 3p21.3 coincide with tumor breakpoints identified by the "elimination test".
TL;DR: A comparative genomic analysis on the CER1 region in Caenorhabditis elegans, Drosophila melanogaster, Fugu rubripes, Gallus gallus, Mus musculus, Rattus norvegicus, and Canis familiaris suggests that regional structural instability is expressed in both evolutionary and cancer-associated chromosome rearrangements.
18
Analysis of copy number variation in the normal human population within a region containing complex segmental duplications on 22q11 using high-resolution array-CGH.
Cecilia de Bustos,Teresita Díaz de Ståhl,Arkadiusz Piotrowski,Arkadiusz Piotrowski,Kiran Kumar Mantripragada,Patrick G. Buckley,Eva Darai,Caisa M. Hansson,Gintautas Grigelionis,Uwe Menzel,Jan P. Dumanski,Jan P. Dumanski +11 more
TL;DR: This array platform allows the detection of DNA copy number variation within regions of pronounced genomic complexity, which constitutes an improvement over available technologies.
16
Comparative human/murine sequence analysis of the common eliminated region 1 from human 3p21.3.
Hajnalka Kiss,Eva Darai,Csaba Kiss,Maria Kost-Alimova,George Klein,Jan P. Dumanski,Stephan Imreh +6 more
TL;DR: A large number of conserved elements were recognized that were neither exons, CpG islands, nor repeats of human Chromosome 3p21.3 to mouse Chr 9F.