15 Papers
92 Citations
Eunsil Cho is an academic researcher from Korea Institute of Science and Technology. The author has contributed to research in topics: Long-term potentiation & Palmitoylation. The author has an hindex of 10, co-authored 14 publications. Previous affiliations of Eunsil Cho include Asan Medical Center & University of Ulsan.
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Papers
Palmitoylation in Alzheimer's disease and other neurodegenerative diseases.
TL;DR: This review will provide and discuss current understandings on palmitoyation/depalmitoylation control mediated by PATs and/or protein thioesterases for neuronal functions in general and also for Alzheimer's disease in particular, and other neurodegenerative diseases such as Huntington's disease, schizophrenia and intellectual disability.
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Alteration of the cerebral zinc pool in a mouse model of Alzheimer disease.
TL;DR: Extensive alterations of ZnT3-regulated Zn2+ pools in the brains of human amyloid precursor protein-transgenic mice suggest that extensive modifications of the cerebral Zn1+ pool, particularly synaptic Zn 2+, may underlie neuronal dysfunction characteristic of Alzheimer disease.
Endogenous zinc mediates apoptotic programmed cell death in the developing brain.
Eunsil Cho,Jung-Jin Hwang,Seung Hee Han,Sun Ju Chung,Jae-Young Koh,Jae-Young Koh,Joo Yong Lee,Joo Yong Lee +7 more
TL;DR: It is demonstrated that intracerebral zinc chelation may arrest PCD in the developing brain by interfering with the caspase-dependent apoptotic pathway, the first in vivo evidence that endogenous labile zinc causes neuronal apoptosis.
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Upregulation of tPA/plasminogen proteolytic system in the periphery of amyloid deposits in the Tg2576 mouse model of Alzheimer's disease.
Joo Yong Lee,Hee Seok Kweon,Eunsil Cho,Jee Young Lee,Hyae ran Byun,Dong Hou Kim,Yang-Hee Kim,Pyung Lim Han,Jae-Young Koh +8 more
TL;DR: The assembled Abeta42 may promote upregulation of the tPA/plasminogen proteolytic system, which can modulate the deposition of amyloid plaques in vivo.
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Cytosolic labile zinc accumulation in degenerating dopaminergic neurons of mouse brain after MPTP treatment.
Joo Yong Lee,Hyo Jin Son,Ji Hyun Choi,Eunsil Cho,Jean Kim,Jean Kim,Sun Ju Chung,Onyou Hwang,Jae-Young Koh,Jae-Young Koh +9 more
TL;DR: The supposition that cytosolic labile zinc accumulation is an indicator of degenerating dopaminergic neurons in animal models of Parkinson's disease is supported.
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