Eung-Seok Lee
Yeungnam University
213 Papers
1.4K Citations
Eung-Seok Lee is an academic researcher from Yeungnam University. The author has contributed to research in topics: Topoisomerase & Chemistry. The author has an hindex of 34, co-authored 209 publications. Previous affiliations of Eung-Seok Lee include Ewha Womans University.
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Papers
2,4,6‐Trisubstituted Pyridines: Synthesis, Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure—Activity Relationship.
Arjun Basnet,Pritam Thapa,Radha Karki,Younghwa Na,Yurngdong Jahng,Byeong-Seon Jeong,Tae Cheon Jeong,Chong-Soon Lee,Eung-Seok Lee +8 more
TL;DR: Structural-activity relationship study indicates that 4'-pyridine at 6-position of central pyridine plays a key role in biological activity.
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Effects of flupyrazofos on liver microsomal cytochrome P450 in the male Fischer 344 rat.
Hye Suk Lee,Hee Yong Lee,Hee Kyoung Gu,Sang Seop Han,Chul-Ho Yun,Jeong-Han Kim,Jung-Ae Kim,Eung-Seok Lee,Doo-Hyun Nam,Tae Cheon Jeong +9 more
TL;DR: It is indicated that flupyrazofos modulates the expression of cytochrome P450 in rat and in Western immunoblotting, cyto Chrome P4502B1/2 proteins were clearly induced by treatment with flupYraz ofos, whereas P4501A1/1 and 2C6 proteins were reduced in liver microsomes.
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Synthesis of 2,4-Diaryl Chromenopyridines and Evaluation of Their Topoisomerase I and II Inhibitory Activity, Cytotoxicity, and Structure—Activity Relationship.
TL;DR: In this article, three chromenopyridines, substituted at the 2-and 4-position with 5-or 6-membered heteroaromatics, are synthesized by treatment of pyridinium iodide salts (III) with chromanones (IV) utilizing a modified Kroehnke synthesis.
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Determination of 1-furan-2-yl-3-pyridin-2-yl-propenone, an anti-inflammatory propenone compound, by high performance liquid chromatography with ultraviolet spectrometry.
TL;DR: Pharmacokinetic parameters for FPP-3 and its metabolites were determined at the same time by using high-performance liquid chromatography-ultraviolet spectrometry and the intra- and inter-day precision and accuracy over the concentration range of target compounds were within 13.5 and 14.2%, respectively.
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Synthesis and COX Inhibitory Activities of Rutaecarpine Derivatives.
Eung-Seok Lee,Seung Ill Kim,Seung Hoo Lee,Tae Cheon Jeong,Tae Chul Moon,Hyeun Wook Chang,Yurngdong Jahng +6 more
TL;DR: In this article, a series of substituted rutaecarpines were prepared by employing Fischer indole synthesis as key step and their inhibitory activities on COX-1 and 2 as well as selectivity was evaluated.
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