Eugene Goldwasser
University of Chicago
122 Papers
2.5K Citations
Eugene Goldwasser is an academic researcher from University of Chicago. The author has contributed to research in topics: Erythropoietin & Erythropoiesis. The author has an hindex of 45, co-authored 122 publications. Previous affiliations of Eugene Goldwasser include United States Atomic Energy Commission & Argonne National Laboratory.
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Papers
Co-regulation of heme oxygenase and erythropoietin genes.
Nader G. Abraham,Richard D. Levere,Richard D. Levere,Jane H.-C. Lin,Nega Beru,Olivier Hermine,Eugene Goldwasser +6 more
TL;DR: The fact that CoCl2 caused increased transcription of both the epo and heme oxygenase genes suggests that a common mechanism may be involved in the regulation of these two genes by the heavy metal ion.
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Electron microscopic localization of lacZ expression in the proximal convoluted tubular cells of the kidney in transgenic mice carrying chimeric erythropoietin/lacZ gene constructs.
Mohammad A. Haidar,Francisco Loya,Yun Yang,Huai Lin,Armand B. Glassman,Eugene Goldwasser,Maher Albitar +6 more
TL;DR: In this article, light and transmission electron microscopic examination of lacZ expression in the kidneys of transgenic mice carrying the 5′-lacZ construct and two additional constructs carrying the 6.5-kb 3′-flanking sequence was performed.
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•Journal Article
Production of erythropoietin by cloned malignant murine erythroid cells.
J. Choppin,Nicole Casadevall,Catherine Lacombe,Françoise Wendling,Eugene Goldwasser,Berger R,Tambourin P,Bruno Varet +7 more
TL;DR: Cloned IW32 and NN10 cells were shown to retain both the ability for erythroid differentiation after incubation with chemical inducers and the ability to produce epo, demonstrating that malignant erythyroid cells were the source of epo production in these cell lines.
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Stabilization of urinary erythropoietin
TL;DR: The instability of erythropoietin derived from human urine may be due to protease and/or sialidase action, and extraction of the hormone into phenol and subsequent precipitation with alcohol results in a marked increase in stability without appreciable loss of activity.
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The frequency of bone marrow cells that bind erythropoietin.
TL;DR: The frequencies of rat and mouse bone marrow cells capable of binding erythropoietin were studied by both direct fluorescence and indirect immunofluorescence and it was found that between 1–2% of the cells bound ERYthropoetin, that the binding was specific, and that the number of cells that bound erythroietin was in part, a function of the erymorphic state of the donor animal.
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