Ethan M. Weiner
University of California, Los Angeles
5 Papers
Ethan M. Weiner is an academic researcher from University of California, Los Angeles. The author has contributed to research in topics: Sortase & Sortase A. The author has an hindex of 4, co-authored 5 publications. Previous affiliations of Ethan M. Weiner include University of California, Berkeley.
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Papers
Sortase enzymes in Gram‐positive bacteria
TL;DR: This work reviews what is known about the functions of sortase enzymes and the molecular basis of catalysis and places particular emphasis on ‘pilin’ specific class C sortases that construct structurally complex pili.
The Sortase A enzyme that attaches proteins to the cell wall of Bacillus anthracis contains an unusual active site architecture.
TL;DR: It is proposed that the presence of a structurally ordered amino terminus positioned within the active site and in contact with catalytically essential histidine residue mediates the recognition of lipid II, the second substrate to which proteins are attached during the anchoring reaction.
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Interaction between Reverse Transcriptase and Integrase Is Required for Reverse Transcription during HIV-1 Replication
Shewit S. Tekeste,Thomas A. Wilkinson,Ethan M. Weiner,Xiaowen Xu,Jennifer T. Miller,Stuart F.J. Le Grice,Robert T. Clubb,Samson A. Chow +7 more
TL;DR: The results indicate that the RT-IN interaction is functionally relevant during the reverse transcription step of the HIV-1 life cycle and can be exploited as a new antiviral drug target.
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NMR structure-based optimization of Staphylococcus aureus sortase A pyridazinone inhibitors.
Albert H. Chan,Sung Wook Yi,Ethan M. Weiner,Brendan R. Amer,Christopher K. Sue,Jeff Wereszczynski,Carly A. Dillen,Silvia Senese,Jorge Z. Torres,J. Andrew McCammon,Lloyd S. Miller,Michael E. Jung,Robert T. Clubb +12 more
TL;DR: This work shows that pyridazinone analogues are attractive candidates for further development into anti‐infective agents, and highlights the utility of employing NMR spectroscopy and solubility‐optimized small molecules in structure‐based drug discovery.
•Posted Content
Defining a Natural Phenomenon After Prometheus
TL;DR: The authors argued that the Prometheus decision obfuscated not only the methodology of examining a process claim relying on a natural phenomenon, but also the very understanding of the natural phenomenon itself, and pointed out that it was not the guiding beacon for patentable subject matter that the PTO, the Federal Circuit, and inventors anxiously awaited.