Ester Lázaro
Spanish National Research Council
54 Papers
517 Citations
Ester Lázaro is an academic researcher from Spanish National Research Council. The author has contributed to research in topics: Population & Viral quasispecies. The author has an hindex of 20, co-authored 48 publications. Previous affiliations of Ester Lázaro include Organon International & Instituto Nacional de Técnica Aeroespacial.
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Papers
Suppression of viral infectivity through lethal defection
TL;DR: This work reports about persistent infections of lymphocytic choriomeningitis virus treated with fluorouracil, where a progressive debilitation of infectivity leading to eventual extinction occurs and proposes that a fraction of the RNA molecules synthesized can behave as a defective subpopulation able to drive the viable class extinct.
Quasispecies dynamics and RNA virus extinction
TL;DR: Experimental results and theoretical models are reviewed that describe a contrast between the effective extinction of FMDV subjected to increased mutagenesis, and the remarkable resistance to extinction of the same and related F MDV clones subjected to serial bottleneck events.
108
High mutation rates, bottlenecks, and robustness of RNA viral quasispecies
TL;DR: This contribution reviews experimental observations regarding the survival of RNA viruses and explores the relationship between the number of replication rounds that a single founder particle undergoes before the next bottleneck is applied, and the mutation rate in a particular environment.
101
Molecular intermediates of fitness gain of an RNA virus: characterization of a mutant spectrum by biological and molecular cloning.
TL;DR: The results underline the observation that greater insight into evolutionary processes of viruses may be gained from detailed clonal analyses of the mutant swarms at the sequence level.
94
Analysis of Ribavirin Mutagenicity in Human Hepatitis C Virus Infection
Stéphane Chevaliez,Rozenn Brillet,Rozenn Brillet,Ester Lázaro,Christophe Hézode,Christophe Hézode,Jean-Michel Pawlotsky,Jean-Michel Pawlotsky +7 more
TL;DR: The hypothesis whereby ribavirin acts as an HCV mutagen in vivo is undermined, as the rate of variation of the consensus sequence, the mutation frequency, the error generation rate, or the between-sample genetic distance was measured.