Esin Aki-Yalcin
Ankara University
22 Papers
44 Citations
Esin Aki-Yalcin is an academic researcher from Ankara University. The author has contributed to research in topics: Pharmacophore & Chemistry. The author has an hindex of 6, co-authored 18 publications.
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Papers
Homology modeling in drug discovery: Overview, current applications, and future perspectives.
TL;DR: There has been the clarification of protein interactions using 3D structures of proteins that are built with homology modeling, which contributes to the identification of novel drug candidates.
304
Molecular Docking: Principles, Advances, and its Applications in Drug Discovery
Muhammed Tilahun Muhammed,Esin Aki-Yalcin +1 more
- 22 Sep 2022
TL;DR: Molecular docking has played a crucial role in making drug discovery faster, cheaper, and more effective and more applications that will make drug discovery easier are expected.
83
Pharmacophore Modeling in Drug Discovery: Methodology and Current Status
TL;DR: Improvements in the quality of the phamacophore models generated have been achieved with the integration of the other computational methods and advances in the latest algorithms, programs that have better perfomance are emerging.
Synthesis and biological evaluation of 2-substituted-5-(4-nitrophenylsulfonamido)benzoxazoles as human GST P1-1 inhibitors, and description of the binding site features.
Tugba Ertan-Bolelli,Yaman Musdal,Kayhan Bolelli,Serap Yilmaz,Yasemin Aksoy,Ilkay Yildiz,Esin Aki-Yalcin,Ismail Yalcin +7 more
TL;DR: The design and synthesis of some novel sulfonamide‐containing benzoxazoles, which are able to inhibit human GST P1‐1 are reported, and 2‐(4‐chlorobenzyl)‐5‐ (4‐nitrophenylsulfonamido)benzoxazole (5 f) was found as the most active hGST P 1‐1 inhibitor, with an IC50 value of 10.2 μM, showing
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Synthesis, Antimicrobial Activity, and Molecular Modeling Studies of Some Benzoxazole Derivatives
Muhammed Tilahun Muhammed,Gulcan Kuyucuklu,Fatma Kaynak-Onurdag,Esin Aki-Yalcin +3 more
- 08 Apr 2022
TL;DR: Although antibacterial activity by inhibiting DNA gyrase is selective, the synthesized compounds were active at much higher concentrations than the standards, and it is better to focus on benzoxazole derivatives without the methylene bridge in prospective antimicrobial studies.
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