Ernst A. Singer
University of Vienna
78 Papers
1.1K Citations
Ernst A. Singer is an academic researcher from University of Vienna. The author has contributed to research in topics: Dopamine & Amphetamine. The author has an hindex of 29, co-authored 78 publications. Previous affiliations of Ernst A. Singer include Medical University of Vienna & Vienna General Hospital.
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Papers
•Journal Article
Mechanism of the dopamine-releasing actions of amphetamine and cocaine: plasmalemmal dopamine transporter versus vesicular monoamine transporter.
TL;DR: The results indicate that there is a plasmalemmal component and a vesicular component in the dopamine-releasing action of amphetamine, and the releasing action of cocaine is dependent on the existence of a vESicular pool of the neurotransmitter and seems to be linked to inhibition of the plas malemmal dopamine transporter.
191
Amphetamines take two to tango: an oligomer-based counter-transport model of neurotransmitter transport explores the amphetamine action
Stefan Seidel,Ernst A. Singer,Herwig Just,Hesso Farhan,Petra Scholze,Oliver Kudlacek,Marion Holy,Karl Koppatz,Peter Krivanek,Michael Freissmuth,Harald H. Sitte +10 more
TL;DR: It is proposed that, in the presence of amphetamine analogs, monoamine transporters operate as counter-transporters; influx and efflux occur through separate but coupled moieties.
Enhanced serotonin transporter function during depression in seasonal affective disorder.
Matthäus Willeit,Harald H. Sitte,N. Thierry,Klaus G. Michalek,Nicole Praschak-Rieder,Peter Zill,Dietmar Winkler,Werner Brannath,Michael B. Fischer,Brigitta Bondy,Siegfried Kasper,Ernst A. Singer +11 more
TL;DR: It is concluded that the 5-HTT is in a hyperfunctional state during depression in SAD and normalizes after light therapy and in natural summer remission.
103
The Role of Zinc Ions in Reverse Transport Mediated by Monoamine Transporters
Petra Scholze,Lene Norregaard,Ernst A. Singer,Michael Freissmuth,Ulrik Gether,Harald H. Sitte +5 more
TL;DR: The observations provide evidence against the model of facilitated exchange-diffusion and support the concept that inward and outward transport represent discrete operational modes of the transporter, and indicate a physiological role of Zn2+, because Zn 2+ also facilitated transport reversal of DAT in rat striatal slices.
96