Erming Wang

TL;DR: In this article, the authors identify three major molecular subtypes of Alzheimer's disease corresponding to different combinations of multiple dysregulated pathways, such as susceptibility to tau-mediated neurodegeneration, amyloid-β neuroinflammation, synaptic signaling, immune activity, mitochondria organization, and myelination.

TL;DR: This study provides not only a global landscape but also detailed signaling circuits of complex molecular interactions in key brain regions affected by LOAD, and the resulting network models will serve as a blueprint for developing next-generation therapeutic agents against LOAD.

TL;DR: RNA sequencing analysis of Gja1−/− astrocytes validated that GJA1 regulated the subnetwork identified in AD, and many genes involved in Aβ metabolism, and its potential for further investigation as a promising pharmacological target in AD.

TL;DR: This study advances the understanding of LOAD pathogenesis by providing the global landscape and detailed circuits of complex molecular interactions and regulations in several key brain regions affected by LOAD and the resulting network models provide a blueprint for developing next generation therapeutics against LOAD.