Erkki Raulo
University of Helsinki
13 Papers
426 Citations
Erkki Raulo is an academic researcher from University of Helsinki. The author has contributed to research in topics: Neurite & Pleiotrophin. The author has an hindex of 11, co-authored 13 publications. Previous affiliations of Erkki Raulo include University of North Carolina at Chapel Hill & Shiga University of Medical Science.
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Papers
Osteoblast Recruitment and Bone Formation Enhanced by Cell Matrix–associated Heparin-binding Growth-associated Molecule (HB-GAM)
Shinji Imai,Marko Kaksonen,Erkki Raulo,Tarja Kinnunen,Carole Fages,Xiaojuan Meng,Merja Lakso,Heikki Rauvala +7 more
TL;DR: It is shown here that heparin-binding growth-associated molecule (HB-GAM), an extracellular matrix–associated protein that enhances migratory responses in neurons, is prominently expressed in the cell matrices that act as target substrates for bone formation.
Neurite Outgrowth in Brain Neurons Induced by Heparin-binding Growth-associated Molecule (HB-GAM) Depends on the Specific Interaction of HB-GAM with Heparan Sulfate at the Cell Surface
TL;DR: Structural analysis of N-syndecan from 6-day-old rat brain indicated that the heparan sulfate chains contain sequences of contiguous, N-sulfated disaccharide units with an unusually high proportion (82%) of 2-O-Sulfated iduronic acid residues, which is suggested to be essential for HB-GAM binding and induction of neurite outgrowth.
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Secretion and biological activities of heparin-binding growth-associated molecule. Neurite outgrowth-promoting and mitogenic actions of the recombinant and tissue-derived protein.
TL;DR: A recombinant baculovirus is constructed using the cDNA that encodes the putative preprotein of HB-GAM and a 17-kDa protein (p17) that is detached from heparin by a slightly higher salt concentration is suggested to be responsible for the mitogenic actions of tissue-derived HB- GAM fractions.
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Heparin-binding Growth-associated Molecule Contains Two Heparin-binding β-Sheet Domains That Are Homologous to the Thrombospondin Type I Repeat
Ilkka Kilpeläinen,Marko Kaksonen,Tarja Kinnunen,Hanna Avikainen,Melissa A. Fath,Robert J. Linhardt,Erkki Raulo,Heikki Rauvala +7 more
TL;DR: It is suggested that the TSR sequence motif found in various extracellular proteins defines a β-sheet structure similar to that found in HB-GAM and midkine, and a similarity in biological functions is suggested by the occurrence of the T SR sequence motif in a wide variety of proteins that mediate cell-to-extracellular matrix and cell- to-cell interactions.
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The role of heparin-binding growth-associated molecule (HB-GAM) in the postsynaptic induction in cultured muscle cells
TL;DR: HB-GAM is an endogenous muscle-derived factor that may be a component of the molecular mechanism in postsynaptic induction of nerve- induced formation of AChR clusters.
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