Erin O’Brien
Takeda Pharmaceutical Company
3 Papers
13 Citations
Erin O’Brien is an academic researcher from Takeda Pharmaceutical Company. The author has contributed to research in topics: Chemistry & Borylation. The author has an hindex of 3, co-authored 3 publications.
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Papers
Development and Scale-up of an Efficient Miyaura Borylation Process Using Tetrahydroxydiboron
Sing R. Gurung,Christopher Mitchell,Jie Huang,Marco Jonas,Josiah D. Strawser,Elena Daia,Andrew Hardy,Erin O’Brien,Frederick Hicks,Charles D. Papageorgiou +9 more
TL;DR: In this paper, a revised Miyaura borylation process was developed using tetrahydroxydiboron that avoids the use of bis(pinacolato) diborons and hence the need to hydrolyze the resulting boronic ester to its corresponding acid.
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A Nitrogen-Assisted One-Pot Heteroaryl Ketone Synthesis from Carboxylic Acids and Heteroaryl Halides.
Krystyna Demkiw,Hirofumi Araki,Eric L. Elliott,Christopher L. Franklin,Yoonjoo Fukuzumi,Frederick Hicks,Kazushi Hosoi,Tadashi Hukui,Yoichiro Ishimaru,Erin O’Brien,Yoshimasa Omori,Masahiro Mineno,Hideya Mizufune,Naotaka Sawada,Yasuhiro Sawai,Lei Zhu +15 more
TL;DR: The results reveal that the presence of an α-nitrogen on the halide substrate greatly improves the desired ketone formation and expands the substrate scope of carboxylic acids with high functional group tolerance.
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Process Development and GMP Production of a Potent NAE Inhibitor Pevonedistat
Ian Armitage,Eric L. Elliott,Frederick Hicks,Marianne Langston,Ashley McCarron,Quentin J. McCubbin,Erin O’Brien,Matt Stirling,Lei Zhu +8 more
TL;DR: In this article, a practical NEDD8-activating enzyme (NAE) inhibitor pevonedistat (MLN4924) is described, which is an enantioselective synthesis of an amino-diol cyclopentane intermediate containing three chiral centers and a novel, regiose-lective sulfamoylation using N-(tert-butoxycarbonyl)-N-[triethylenediammonium)sulfonyl]azanide.
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