Erin C. Hedges
King's College London
5 Papers
Erin C. Hedges is an academic researcher from King's College London. The author has contributed to research in topics: Neurogenesis & Induced pluripotent stem cell. The author has an hindex of 2, co-authored 5 publications.
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Papers
Telomere length and human hippocampal neurogenesis
Alish B. Palmos,Rodrigo R.R. Duarte,Rodrigo R.R. Duarte,Demelza Smeeth,Erin C. Hedges,Douglas F. Nixon,Sandrine Thuret,Sandrine Thuret,Timothy R. Powell,Timothy R. Powell +9 more
TL;DR: The results suggest that telomere shortening could represent a mechanism that moderates the proliferative capacity of human hippocampal progenitors, which may subsequently impact on human cognitive function and psychiatric disorder pathophysiology.
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Lithium treatment and human hippocampal neurogenesis
Alish B. Palmos,Rodrigo R.R. Duarte,Rodrigo R.R. Duarte,Demelza Smeeth,Erin C. Hedges,Douglas F. Nixon,Sandrine Thuret,Sandrine Thuret,Timothy R. Powell,Timothy R. Powell +9 more
TL;DR: In this article, the effects of low (0.75) and high (2.25) doses of lithium on human hippocampal progenitor cells were investigated and immunocytochemistry was used to evaluate whether genes affected by lithium in their model overlap with those regulating the volume of specific layers of the dentate gyrus.
The impact of telomere shortening on human hippocampal neurogenesis: Implications for cognitive function and psychiatric disorder risk
Alish B. Palmos,Rodrigo R.R. Duarte,Demelza Smeeth,Erin C. Hedges,Douglas F. Nixon,Sandrine Thuret,Timothy R. Powell +6 more
TL;DR: The results suggest that reductions in adult hippocampal neurogenesis, caused by telomere shortening, could represent a cellular mechanism contributing to age-related cognitive impairment and psychiatric disorder risk.
Generation of six induced pluripotent stem cell lines from patients with amyotrophic lateral sclerosis with associated genetic mutations in either FUS or ANXA11.
TL;DR: The authors derived induced pluripotent stem cell (iPSC) lines from six ALS patient lymphoblastoid cell lines, three with mutations in FUS (Q519E, R521H, R522G), and three mutations in ANXA11 (G38R, D40G, R235Q).
The Use of Stem Cells to Model Amyotrophic Lateral Sclerosis and Frontotemporal Dementia: From Basic Research to Regenerative Medicine.
TL;DR: This review discusses how patient specific induced pluripotent stem cells (iPSCs) have been used to model ALS and FTD and the most recent drug screening targets for these diseases and how an iPSC bank would improve the quality of the available cell lines.